DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, J | - |
dc.contributor.author | Cho, JH | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Ha, SJ | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T12:35:08Z | - |
dc.date.available | 2016-03-31T12:35:08Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2004-03-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2004-OAK-0000004063 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18064 | - |
dc.description.abstract | Antigenic and costimulatory signals trigger a developmental program by which naive CD8 T cells differentiate into effector and memory cells. However, initial cytokine signals that regulate the generation of effector and memory CD8 T cells are not well understood. In this study, we show that IL-12 priming during in vitro antigenic stimulation results in the significant increase of both primary and memory CD8 T cell population in mice after adoptive transfer of activated cells. The effect of IL-12 priming is closely associated with qualitative changes in CD8 T cells, such as reduced MHC I tetramer binding and CD69 expression, altered distribution of lipid rafts, decreased cytolytic activity, and less susceptibility to apoptosis. Furthermore, exogenous IL-12 priming improved the intrinsic survival properties of memory CD8 T cells, leading to better protective immunity and vaccine-induced memory CD8 T cell responses. However, the experiments with IL-12p40- and IL-12Rbeta1-deficient mice showed similar levels of primary and memory CD8 T cell responses compared with wild-type mice, implying that endogenous IL-12 and/or IL-12R signaling in vivo is not critical for CD8 T cell immunity. Together, our results suggest that IL-12 can serve as an important, but dispensable regulatory factor for the development of CD8 T cells, and IL-12 priming could be useful in many medical applications. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | MHC CLASS-I | - |
dc.subject | CUTTING EDGE | - |
dc.subject | CLONAL EXPANSION | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | 3RD SIGNAL | - |
dc.subject | ACTIVATION | - |
dc.subject | CD4(+) | - |
dc.subject | NAIVE | - |
dc.subject | DEATH | - |
dc.subject | DIFFERENTIATION | - |
dc.title | IL-12 priming during in vitro antigenic stimulation change's properties of CD8 T cells and increases generation of effector and memory cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.172.5.2818 | - |
dc.author.google | Chang, J | - |
dc.author.google | Cho, JH | - |
dc.author.google | Lee, SW | - |
dc.author.google | Choi, SY | - |
dc.author.google | Ha, SJ | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 172 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 2818 | - |
dc.relation.lastpage | 2826 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.172, no.5, pp.2818 - 2826 | - |
dc.identifier.wosid | 000189186000017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2826 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2818 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 172 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-1342303472 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 48 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MHC CLASS-I | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | CLONAL EXPANSION | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | 3RD SIGNAL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CD4(+) | - |
dc.subject.keywordPlus | NAIVE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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