Incorporation and release behavior of hydrophobic drug in functionalized poly(D,L-lactide)-block-poly(ethylene oxide) micelles
SCIE
SCOPUS
- Title
- Incorporation and release behavior of hydrophobic drug in functionalized poly(D,L-lactide)-block-poly(ethylene oxide) micelles
- Authors
- Lee, JY; Cho, EC; Cho, K
- Date Issued
- 2004-02-10
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- The poly(ethylene oxide)-poly(lactide) (PEO-PLA) block copolymers containing a small quantity of carboxylic acid in the PLA block were synthesized. The microscopic characteristics of nanoparticles with carboxylic acid content in the copolymer were analyzed, and the effect of specific interactions between the copolymer and the model drug on the drug loading capacity and the release behavior were investigated systematically. The sizes of nanoparticles prepared by a dialysis method are within the range of 30-40 nm. The nanoparticles prepared from functionalized block copolymers have a very low critical micelle concentration (CMC) value as low as similar to10(-3) mg/ml, which indicates a good stability of the nanoparticles in spite of the presence of carboxylic acid. The drug loading efficiency of nanoparticles dramatically increased when carboxylic acid content was increased in the block copolymer. This result may be attributed to the increase of interactions between the copolymer and the drug. The release rate of the drug was much slower from nanoparticles containing higher amounts of carboxylic acid in the copolymer, which might be associated with the enhanced interaction between the carboxylic group of copolymers and the drug. These experimental results suggest that the nanoparticles prepared from functionalized PEO-PLA block copolymers could be a good candidate for an injectable drug delivery carrier. (C) 2003 Elsevier B.V. All rights reserved.
- Keywords
- block copolymer; micelle; nanoparticle; drug delivery; careboxylic acid; BLOCK-COPOLYMER MICELLES; POLY(ETHYLENE OXIDE); POLYMERIC MICELLES; POLY(BETA-BENZYL L-ASPARTATE); DELIVERY SYSTEMS; ACID); ADRIAMYCIN; CARRIERS; SOLVENTS; DESIGN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/18095
- DOI
- 10.1016/j.jconrel.2003.10.012
- ISSN
- 0168-3659
- Article Type
- Article
- Citation
- JOURNAL OF CONTROLLED RELEASE, vol. 94, no. 2-3, page. 323 - 335, 2004-02-10
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