DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, J | - |
dc.contributor.author | Yang, HC | - |
dc.contributor.author | de Beus, MD | - |
dc.contributor.author | Ryu, CY | - |
dc.contributor.author | Cho, K | - |
dc.contributor.author | Colon, W | - |
dc.date.accessioned | 2016-03-31T12:41:08Z | - |
dc.date.available | 2016-03-31T12:41:08Z | - |
dc.date.created | 2009-08-25 | - |
dc.date.issued | 2003-12-26 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2004-OAK-0000003883 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18198 | - |
dc.description.abstract | Mutations in Cu/Zn superoxide dismutase (SOD) are associated with familial amyotrophic lateral sclerosis (FALS), a neuro-degenerative disease that is characterized by the selective death of motor neurons. Despite the genetic association made between the protein and the disease, the mechanism by which the mutant SOD proteins become toxic is still a mystery. Using wild-type SOD and three pathogenic mutants (A4V, G37R, and G85R), we show that the copper-induced oxidation of metal-depleted SOD causes its in vitro aggregation into pore-like structures, as determined by atomic force microscopy. Because toxic pores have been recently implicated in the pathogenic mechanism of other neurodegenerative diseases, these results raise the possibility that the aberrant self-assembly of oxidatively damaged SOD mutants into toxic oligomers or pores may have a pathological role in FALS., (C) 2003 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | aggregation | - |
dc.subject | amyloid | - |
dc.subject | amyotrophic lateral sclerosis | - |
dc.subject | neurodegeneration | - |
dc.subject | channel | - |
dc.subject | pore | - |
dc.subject | SOD | - |
dc.subject | FALS | - |
dc.subject | oxidative damage | - |
dc.subject | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject | MUTATIONS | - |
dc.subject | DISEASE | - |
dc.subject | VACUOLIZATION | - |
dc.subject | MECHANISM | - |
dc.subject | OXIDATION | - |
dc.subject | DAMAGE | - |
dc.subject | DEATH | - |
dc.subject | MICE | - |
dc.subject | SOD1 | - |
dc.title | Cu/Zn superoxide dismutase can form pore-like structures | - |
dc.type | Article | - |
dc.contributor.college | 화학공학과 | - |
dc.identifier.doi | 10.1016/j.bbrc.2003.11.008 | - |
dc.author.google | Chung, J | - |
dc.author.google | Yang, HC | - |
dc.author.google | de Beus, MD | - |
dc.author.google | Ryu, CY | - |
dc.author.google | Cho, K | - |
dc.author.google | Colon, W | - |
dc.relation.volume | 312 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 873 | - |
dc.relation.lastpage | 876 | - |
dc.contributor.id | 10077904 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.312, no.4, pp.873 - 876 | - |
dc.identifier.wosid | 000187252300002 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 876 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 873 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 312 | - |
dc.contributor.affiliatedAuthor | Cho, K | - |
dc.identifier.scopusid | 2-s2.0-0344495441 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 35 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | AMYOTROPHIC-LATERAL-SCLEROSIS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | VACUOLIZATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | SOD1 | - |
dc.subject.keywordAuthor | aggregation | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordAuthor | amyotrophic lateral sclerosis | - |
dc.subject.keywordAuthor | neurodegeneration | - |
dc.subject.keywordAuthor | channel | - |
dc.subject.keywordAuthor | pore | - |
dc.subject.keywordAuthor | SOD | - |
dc.subject.keywordAuthor | FALS | - |
dc.subject.keywordAuthor | oxidative damage | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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