DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, SH | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Lee, CG | - |
dc.contributor.author | Youn, JW | - |
dc.contributor.author | Chang, J | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T12:42:18Z | - |
dc.date.available | 2016-03-31T12:42:18Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-11-07 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.other | 2003-OAK-0000003850 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18225 | - |
dc.description.abstract | Hepatitis C virus (HCV) is an important causative agent of liver disease, but currently there is no available prophylactic vaccine against HCV infection. Here, we investigated the HCV E2- and core-specific T-cell responses induced by DNA (D) and/or recombinant adenovirus (A) vaccines. In single (D versus A) or double immunizations (D-D versus A-A), the recombinant adenovirus vaccines induced higher levels of IFN-gamma secreting T-cell response and cytotoxic T lymphocytes (CTL) response than the DNA vaccines. However, a heterologous (D-A) regimen elicited the highest level of T helper 1 (Th1) CD4(+) T-cell responses. Furthermore, three E2-specific CTL epitopes were mapped using a peptide pool spanning the E2 protein sequence (a.a. 384-713) in BALB/c mice, and one of these (E2 405-414: SGPSQKIQLV) was shown to be immunodominant. Interestingly, no significant differences were found in the repertoire of E2-specific T-cell responses or in the immunodominance hierarchy of the three epitopes induced by D-D, D-A, A-A, and A-D, indicating that the breadth and hierarchy of T-cell responses is independent of these different vaccination regimens. In conclusion, the heterologous DNA prime-recombinant adenovirus boost regimen described offers an efficient promising strategy for the development of an effective T-cell-based HCV vaccine. (C) 2003 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | VACCINE | - |
dc.subject | hepatitis C virus | - |
dc.subject | DNA prime-recombinant adenovirus boost | - |
dc.subject | Th1CD4(+) T-cell response | - |
dc.subject | RECOMBINANT ADENOVIRUSES | - |
dc.subject | LYMPHOCYTE RESPONSES | - |
dc.subject | PLASMID DNA | - |
dc.subject | INFECTION | - |
dc.subject | PROTEINS | - |
dc.subject | VACCINE | - |
dc.subject | IMMUNIZATION | - |
dc.subject | MECHANISM | - |
dc.subject | MICE | - |
dc.title | Efficient induction of T helper 1 CD4(+) T-cell responses to hepatitis C virus core and E2 by a DNA prime-adenovirus boost | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0264-410X(03)00499-7 | - |
dc.author.google | Park, SH | - |
dc.author.google | Yang, SH | - |
dc.author.google | Lee, CG | - |
dc.author.google | Youn, JW | - |
dc.author.google | Chang, J | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 21 | - |
dc.relation.issue | 31 | - |
dc.relation.startpage | 4555 | - |
dc.relation.lastpage | 4564 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | VACCINE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | VACCINE, v.21, no.31, pp.4555 - 4564 | - |
dc.identifier.wosid | 000186830900010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 4564 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 4555 | - |
dc.citation.title | VACCINE | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0142231018 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 33 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RECOMBINANT ADENOVIRUSES | - |
dc.subject.keywordPlus | LYMPHOCYTE RESPONSES | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | IMMUNIZATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | DNA prime-recombinant adenovirus boost | - |
dc.subject.keywordAuthor | Th1CD4(+) T-cell response | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
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