DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Shin, KJ | - |
dc.contributor.author | Kim, D | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Han, MS | - |
dc.contributor.author | Lee, TG | - |
dc.contributor.author | Kim, E | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T12:45:21Z | - |
dc.date.available | 2016-03-31T12:45:21Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-09-15 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.other | 2003-OAK-0000003697 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18329 | - |
dc.description.abstract | Flavonoids are natural polyphenolic compounds that have anti-inflammatory, cytoprotective and anticarcinogenic effects. In this study, we investigated the effects of several flavonoids on nuclear factor-kappa B (NF-kappaB) activation by using luciferase reporter gene assay. Among the flavonoids examined, luteolin showed the most potent inhibition on lipopolysaccharide (LPS)-stimulated NF-kappaB transcriptional activity in Rat-1 fibroblasts. Luteolin did not inhibit either IkappaBalpha. degradation or NF-kappaB nuclear translocation, DNA binding or phosphorylation by LPS. However, luteolin prevented LPS-stimulated interaction between the p65 subunit of NF-kappaB and the transcriptional coactivator CBP. In addition, a specific PKA inhibitor that blocked the phosphorylation of CREB and c-Jun by luteolin partially reversed the inhibitory effect of luteolin on NF-kappaB(.)CBP complex formation and NF-kappaB transcriptional activity by LPS. These data imply that inhibition of NF-kappaB transcriptional activity by luteolin may occur through competition with transcription factors for coactivator that is available in limited amounts. Taken together, this study provides a molecular basis for the understanding of the antiinflammatory effects of luteolin. (C) 2003 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOCHEMICAL PHARMACOLOGY | - |
dc.subject | nuclear factor-kappa B | - |
dc.subject | luteolin | - |
dc.subject | coactivator | - |
dc.subject | lipopolysaccharide | - |
dc.subject | fibroblast | - |
dc.subject | anti-inflammation | - |
dc.subject | CBP-INDUCED STIMULATION | - |
dc.subject | MEDIATED TRANSCRIPTION | - |
dc.subject | PROTEIN CBP | - |
dc.subject | IN-VIVO | - |
dc.subject | FLAVONOIDS | - |
dc.subject | ACTIVATION | - |
dc.subject | COACTIVATOR | - |
dc.subject | CREB | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | INFLAMMATION | - |
dc.title | Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0006-2952(03)00465-9 | - |
dc.author.google | Kim, SH | - |
dc.author.google | Shin, KJ | - |
dc.author.google | Kim, D | - |
dc.author.google | Kim, YH | - |
dc.author.google | Han, MS | - |
dc.author.google | Lee, TG | - |
dc.author.google | Kim, E | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 66 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 955 | - |
dc.relation.lastpage | 963 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | BIOCHEMICAL PHARMACOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL PHARMACOLOGY, v.66, no.6, pp.955 - 963 | - |
dc.identifier.wosid | 000185501200009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 963 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 955 | - |
dc.citation.title | BIOCHEMICAL PHARMACOLOGY | - |
dc.citation.volume | 66 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0042762838 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 55 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CBP-INDUCED STIMULATION | - |
dc.subject.keywordPlus | MEDIATED TRANSCRIPTION | - |
dc.subject.keywordPlus | PROTEIN CBP | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COACTIVATOR | - |
dc.subject.keywordPlus | CREB | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordAuthor | nuclear factor-kappa B | - |
dc.subject.keywordAuthor | luteolin | - |
dc.subject.keywordAuthor | coactivator | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | fibroblast | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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