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Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase SCIE SCOPUS
- Title
- Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase
- Date Issued
- 2003-09-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Scyllo-Inositol phosphates, which are among the stereoisomers of myo-inositol phosphate, can have 15 possible regio-isomers including three enantiomeric pairs: scyllo-I(1,2)P-2, scyllo-I(1,2,4)P-3, Scyllo-I(1,2,3,4)P-4. We herein describe the facile synthetic routes to the three enantiomeric pairs 4 scyllo-inositol phosphate and the molecular interactions between 15 regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Geometry of the enzyme binding site is discussed. (C) 2003 Elsevier Ltd. All rights reserved.
- Keywords
- MYOINOSITOL; BRAIN; POLYPHOSPHATES; IDENTIFICATION; STEREOISOMERS; DERIVATIVES; CONDURITOL; EXPRESSION; INHIBITORS; RESOLUTION
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 18, page. 2981 - 2984, 2003-09-15
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Related Researcher
- 최관용CHOI, KWAN YONG
- Div of Integrative Biosci & Biotech