DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, MS | - |
dc.contributor.author | Shin, KJ | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Lee, T | - |
dc.contributor.author | Kim, E | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T12:49:46Z | - |
dc.date.available | 2016-03-31T12:49:46Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2003-06 | - |
dc.identifier.issn | 0161-813X | - |
dc.identifier.other | 2003-OAK-0000003462 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/18495 | - |
dc.description.abstract | The neurotoxicity of dithiocarbamates has been previously reported, however the detailed mechanism underlying the neurotoxicity is still not fully understood Among the dithiocarbamates, we investigated thiram and ziram in a neuronal-like pheochromocytoma (PC12) cells. Thiram and ziram strongly induced cell death in both dose- and time-dependent manners with the LC50 of 0.3 and 2 muM, respectively. The cell death showed typical apoptotic features, such as DNA fragmentation and an increase of subdiploidy nuclei. Interestingly, both thiram and ziram induced rapid and sustained increases of intracellular Ca2+ in PC12 cells, which were almost completely blocked by flufenamic acid (FFA), an inhibitor of non-selective cation channel. BAPTA-AM, an intracellular Ca2+ chelator inhibited the thiram- and ziraminduced apoptotic cell death. These results suggest that thiram and ziram induce apoptotic neuronal cell death by Ca2+ influx through non-selective cation channels. The present study may provide a clue for understanding the mechanism of neurotoxicity of thiram and ziram. (C) 2003 Published by Elsevier Science Inc. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | NEUROTOXICOLOGY | - |
dc.subject | thiram | - |
dc.subject | ziram | - |
dc.subject | zineb | - |
dc.subject | apoptosis | - |
dc.subject | PC12 cells | - |
dc.subject | non-selective cation channel | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | DITHIOCARBAMATE | - |
dc.subject | CA2+ | - |
dc.subject | RAT | - |
dc.subject | FUNGICIDES | - |
dc.subject | GENOTOXICITY | - |
dc.subject | ACTIVATION | - |
dc.subject | TOXICITY | - |
dc.subject | DISEASE | - |
dc.subject | INVITRO | - |
dc.title | Thiram and ziram stimulate non-selective cation channel and induce apoptosis in PC12 cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0161-813X(03)00013-5 | - |
dc.author.google | Han, MS | - |
dc.author.google | Shin, KJ | - |
dc.author.google | Kim, YH | - |
dc.author.google | Kim, SH | - |
dc.author.google | Lee, T | - |
dc.author.google | Kim, E | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 24 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 425 | - |
dc.relation.lastpage | 434 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | NEUROTOXICOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEUROTOXICOLOGY, v.24, no.3, pp.425 - 434 | - |
dc.identifier.wosid | 000183587100010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 434 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 425 | - |
dc.citation.title | NEUROTOXICOLOGY | - |
dc.citation.volume | 24 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0038348746 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 19 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | DITHIOCARBAMATE | - |
dc.subject.keywordPlus | CA2+ | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordPlus | FUNGICIDES | - |
dc.subject.keywordPlus | GENOTOXICITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordAuthor | thiram | - |
dc.subject.keywordAuthor | ziram | - |
dc.subject.keywordAuthor | zineb | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | PC12 cells | - |
dc.subject.keywordAuthor | non-selective cation channel | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
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