Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors
SCIE
SCOPUS
- Title
- Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors
- Authors
- Lim, HS; Oh, YS; Suh, PG; Chung, SK
- Date Issued
- 2003-01-20
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5. (C) 2002 Elsevier Science Ltd. All rights reserved.
- Keywords
- SPHINGOSINE 1-PHOSPHATE; FAMILY; CELLS; ANGIOGENESIS; MECHANISM; MIGRATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/18736
- DOI
- 10.1016/S0960-894X(02)00893-4
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 2, page. 237 - 240, 2003-01-20
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