IL-12 provides proliferation and survival signals to murine CD4(+) T cells through phosphatidylinositol 3-kinase/Akt signaling pathway
SCIE
SCOPUS
- Title
- IL-12 provides proliferation and survival signals to murine CD4(+) T cells through phosphatidylinositol 3-kinase/Akt signaling pathway
- Authors
- Yoo, JK; Cho, JH; Lee, SW; Sung, YC
- Date Issued
- 2002-10-01
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Abstract
- IL-12 is a pleiotropic cytokine that plays an important role in innate and adaptive immunity. IL-12 induces T cell proliferation and IFN-gamma secretion from activated T cells. It was also reported that IL-12 prevents apoptosis of CD4(+) T cells. However, the signaling mechanism that regulates these IL-12-induced responses is poorly understood yet. In this study, we demonstrated that IL-12 activates phosphatidylinositol 3-kinase (PI3K)/Akt pathway in murine CD4(+) T cells, and that this signaling pathway is required for IL-12-induced T cell proliferation and antiapoptotic function, but not for IFN-gamma induction. Through PI3K/Akt pathway, IL-12 up-regulates the expression of cell cycle-related molecule such as cyclin D3, and antiapoptotic molecules such as Bcl-2 and cellular inhibitors of apoptosis proteins-2, followed by down-regulation of active caspase-3. These results suggest that PI3K/Akt pathway is critical for mediating IL-12-induced CD4(+) T cell responses such as T cell proliferation and survival.
- Keywords
- ACTIVATED PROTEIN-KINASE; TYROSINE PHOSPHORYLATION; SERINE PHOSPHORYLATION; STIMULATORY FACTOR; GAMMA EXPRESSION; APOPTOSIS; INHIBITOR; DEATH; INTERLEUKIN-12; RESPONSES
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/18888
- DOI
- 10.4049/jimmunol.169.7.3637
- ISSN
- 0022-1767
- Article Type
- Article
- Citation
- JOURNAL OF IMMUNOLOGY, vol. 169, no. 7, page. 3637 - 3643, 2002-10-01
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