DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Lee, CG | - |
dc.contributor.author | Lee, CW | - |
dc.contributor.author | Choi, EJ | - |
dc.contributor.author | Yoon, SK | - |
dc.contributor.author | Ahn, KS | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T13:04:27Z | - |
dc.date.available | 2016-03-31T13:04:27Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2002-06-30 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2002-OAK-0000002742 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19010 | - |
dc.description.abstract | The p38 mitogen activated kinase (MAPK) signaling pathway plays an essential role in regulating many cellular processes, including inflammation, cell differentiation, and cell death. Here, we report that the hepatitis C virus (HCV) core inhibits the Fas-mediated p38 signaling pathway. The Fas-mediated p38 activation is suppressed in core-expressing HepG2 cell lines, as well as in the hepatocytes of transgenic mice. In addition, core protein blocked the Fas-mediated activation of apoptosis signal-regulating kinase 1 (ASK1), a major upstream MAPKKK of p38. Treatment of a specific p38 inhibitor (SB203580) or overexpression of a kinase-defective mutant, ASK1 (K709R), promoted Fas-mediated cell death in HepG2 cells. This suggests that the p38 and ASK1 activation is required for cell survival against Fas-mediated cell death. In addition, we observed that the HCV core protein enhances Fas-mediated liver injury and lethality in transgenic mice. Collectively, our findings suggest that the HCV core inhibits the Fas-mediated p38 signaling pathway, which results in accelerated Fas-mediated cell death. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | ASK1 | - |
dc.subject | core | - |
dc.subject | Fas | - |
dc.subject | hepatitis C virus | - |
dc.subject | p38 | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | ICE/CED-3 FAMILY PROTEASES | - |
dc.subject | PROTEIN-KINASE | - |
dc.subject | MAP KINASE | - |
dc.subject | TRANSDUCTION PATHWAY | - |
dc.subject | CELL-DEATH | - |
dc.subject | T-CELLS | - |
dc.subject | APOPTOSIS | - |
dc.subject | LIVER | - |
dc.subject | SURVIVAL | - |
dc.title | Hepatitis C virus core inhibits the fas-mediated p38 mitogen activated kinase signaling pathway in hepatocytes | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Yang, SH | - |
dc.author.google | Lee, CG | - |
dc.author.google | Lee, CW | - |
dc.author.google | Choi, EJ | - |
dc.author.google | Yoon, SK | - |
dc.author.google | Ahn, KS | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 13 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 452 | - |
dc.relation.lastpage | 462 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.13, no.3, pp.452 - 462 | - |
dc.identifier.wosid | 000176557400014 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 462 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 452 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 13 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0013254477 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 22 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | ICE/CED-3 FAMILY PROTEASES | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | TRANSDUCTION PATHWAY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | ASK1 | - |
dc.subject.keywordAuthor | core | - |
dc.subject.keywordAuthor | Fas | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | p38 | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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