Heterocyclic nucleoside analogues: Design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles
SCIE
SCOPUS
- Title
- Heterocyclic nucleoside analogues: Design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles
- Authors
- Lee, YS; Kim, BH
- Date Issued
- 2002-05-20
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis). (C) 2002 Elsevier Science Ltd. All rights reserved.
- Keywords
- IMMUNODEFICIENCY-VIRUS TYPE-1; KETOMETHYLENE DIPEPTIDE ISOSTERES; SELECTIVE ANTI-HIV-1 AGENTS; 1-<(2-HYDROXYETHOXY)METHYL>-6-(PHENYLTHIO)THYMINE HEPT; 2-ISOXAZOLINE; BCH-189; POTENT; TSAO
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19084
- DOI
- 10.1016/S0960-894X(02)00182-8
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 10, page. 1395 - 1397, 2002-05-20
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