DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, YS | - |
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Park, JC | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-03-31T13:09:46Z | - |
dc.date.available | 2016-03-31T13:09:46Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2002-02 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.other | 2002-OAK-0000002464 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19208 | - |
dc.description.abstract | Previously, we showed that Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm) stimulates superoxide generation and chemotactic migration in monocytes and neutrophils. In this study, we examined the effect of WKYMVm on monocyte survival. Serum starvation-induced monocyte death was attenuated in the presence of WKYMVm, which was abated when the cells were preincubated with LY294002, suggesting the involvement of phosphoinositide-3-kinase (PI 3-kinase) in the peptide-induced monocyte survival. WKYMVm stimulated ERK and Akt activity via PI 3-kinase activation in monocytes. We also investigated the signaling pathway of WKYMVm-induced ERK and Akt activation. The WKYMVm-induced ERK activation was PI 3-kinase-dependent but PKC-independent. However, Akt activation by WKYMVm was dependent not only on PI 3-kinase but also on the PKC pathway. When monocytes were incubated with WKYMVm, caspase-3 activity, which is important for cell death, was inhibited. Pretreatment of the cells with LY294002, GF109203X, and Go 6976 but not PD98059 blocked WKYMVm-induced monocyte survival and caspase-3 inhibition. In summary, the novel chemoattractant WKYMVm enhances monocyte survival via Akt-mediated pathways, and in this process, PKC and PI 3-kinase act upstream of Akt. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.subject | PI 3-kinase | - |
dc.subject | ERK | - |
dc.subject | G-protein | - |
dc.subject | caspase-3 | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | CELL-SURVIVAL | - |
dc.subject | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject | SUPEROXIDE GENERATION | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | HEMATOPOIETIC-CELLS | - |
dc.subject | COUPLED RECEPTORS | - |
dc.title | The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Bae, YS | - |
dc.author.google | Kim, Y | - |
dc.author.google | Park, JC | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 71 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 329 | - |
dc.relation.lastpage | 338 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.71, no.2, pp.329 - 338 | - |
dc.identifier.wosid | 000173810900019 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 338 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 329 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 71 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 11 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CELL-SURVIVAL | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject.keywordPlus | SUPEROXIDE GENERATION | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | HEMATOPOIETIC-CELLS | - |
dc.subject.keywordPlus | COUPLED RECEPTORS | - |
dc.subject.keywordAuthor | PI 3-kinase | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | G-protein | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
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