The role of PDR13 in tolerance to high copper stress in budding yeast
SCIE
SCOPUS
- Title
- The role of PDR13 in tolerance to high copper stress in budding yeast
- Authors
- Kim, DY; Song, WY; Yang, YY; Lee, Y
- Date Issued
- 2001-11-09
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- PDR13 in Saccharomyces cerevisiae contributes to drug resistance via sequential activation of PDR1 and PDR5. In this study, we found that a PDR13 deletion mutant was hypersensitive to Cu2+ compared to the wild-type counterpart. The Cu2+ tolerance mechanism mediated by Pdr13 does not seem to involve Pdr1 or Pdr5, since mutants harboring a deletion of either the PDR1 or PDR5 gene did not show elevated Cu2+ sensitivity. Instead, we found that the PDR13 null mutant could not express CUP1 or CRS5 metallothionein at wild-type levels when subjected to high Cu2+ stress. These results suggest that Pdr13 contributes to high Cu2+ tolerance of S. cerevisiae, at least in part, via a mechanism involving metallothionein expression. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
- Keywords
- PDR13; high Cu stress; budding yeast; metallothionein; SACCHAROMYCES-CEREVISIAE; METALLOTHIONEIN GENE; EXPRESSION; TRANSCRIPTION; RESISTANCE; PROTEIN; MUTANTS; HSP70
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19297
- DOI
- 10.1016/S0014-5793(01)03038-1
- ISSN
- 0014-5793
- Article Type
- Article
- Citation
- FEBS LETTERS, vol. 508, no. 1, page. 99 - 102, 2001-11-09
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