Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling
SCIE
SCOPUS
- Title
- Breakthroughs and views - The roles of PDZ-containing proteins in PLC-beta-mediated signaling
- Authors
- Suh, PG; Hwang, JI; Ryu, SH; Donowitz, M; Kim, JH
- Date Issued
- 2001-10-19
- Publisher
- ACADEMIC PRESS INC
- Abstract
- Mammalian phospholipase C-beta isozymes are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Recent reports suggest that PDZ domain proteins play a significant role of PDZ-containing proteins in the regulation of mammalian PLC-beta isozymes. PDZ-containing proteins mediate the clustering of receptors and signaling molecules and thereby regulate agonist-induced signal transduction in polarized cells such as neuronal and epithelial cells. NORPA, a Drosophila PLC-beta, is known to be a component of a signaling complex that includes TRP and rhodopsin through interaction with DIAD, a PDZ-containing protein. Mammalian PLC-beta1 and -beta2 isoforms interact with a PDZ-containing protein NHERF which is coupled to Trp4, a Ca2+ channel. In addition, PLC-beta3 specifically interacts with E3KARP, another protein closely related to NHERF, through its C-terminal PDZ-binding motif. E3KARP up-regulates the PLC-beta3 activation coupled to muscarinic receptor. In this review, the role of signaling complexes mediated by PDZ-containing proteins in the regulation of PLC-beta isoforms will be discussed. (C) 2001 Academic Press.
- Keywords
- G-protein-coupled receptor; INAD; NHERF; E3KARP; PDZ domain; phospholipase C-beta (PLC-beta); Trp; PHOSPHOLIPASE-C ISOZYMES; EXCHANGER REGULATORY FACTOR; KINASE-A; BETA(2)-ADRENERGIC RECEPTOR; DOMAIN INTERACTION; SHANK FAMILY; ASSOCIATION; INAD; ACTIVATION; DROSOPHILA
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19334
- DOI
- 10.1006/bbrc.2001.5710
- ISSN
- 0006-291X
- Article Type
- Article
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 288, no. 1, page. 1 - 7, 2001-10-19
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