DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Y | - |
dc.contributor.author | Chang, YS | - |
dc.contributor.author | Lee, SW | - |
dc.contributor.author | Cho, SY | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Min, KU | - |
dc.contributor.author | Kim, YY | - |
dc.contributor.author | Cho, SH | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-03-31T13:13:15Z | - |
dc.date.available | 2016-03-31T13:13:15Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2001-10 | - |
dc.identifier.issn | 0091-6749 | - |
dc.identifier.other | 2001-OAK-0000002283 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19338 | - |
dc.description.abstract | Background: Oligodeoxynucleotides containing a CpG motif (CpG ODNs), as potent inducers of T(H)1 immunity, are considered promising candidates for immune modulation in asthma. We have previously demonstrated that conjugation of a hexameric deoxyriboguanosine run to the 3' terminus (3' dG(6)-run) of phosphodiester (PE) CpG ODNs enhanced their immunostimulatory activities in vitro. Objective: This study aimed to evaluate the effect of a 3' dG(6)-run conjugation to PE or phosphorothioate (PS) CpG ODNs on protection against murine allergic asthma in vivo. Methods: Balb/c mice were sensitized to ovalbumin by intraperitoneal injection with or without CpG ODNs (PS CpG ODNs, PE CpG ODNs, and those with 3'dG(6)-run) and subsequently challenged with ovalbumin. We evaluated airway hyperresponsiveness, eosinophil proportion in bronchoalveolar lavage fluid, airway inflammation, and ovalbumin-specific antibody responses. Results: The conjugation of a 3' dG(6)-run to PE CpG ODNs enhanced the production of IFN-gamma from ovalbumin-specific T-H cells and prevented the development of asthma in terms of airway hyperresponsiveness, airway eosinophilia, and ovalbumin-specific IgE responses; these effects were comparable to those of PS CpG ODNs. Enhanced effects of the 3' dG(6)-run were also observed in PS CpG ODNs, though they were lower than those in PE CpG ODNs. Conclusion: This study suggests that conjugation of a 3' dG(6)-run to CpG ODNs might provide an effective method for immune modulation of allergic asthma. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | MOSBY, INC | - |
dc.relation.isPartOf | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.subject | asthma | - |
dc.subject | CpG oligodeoxynucleotides | - |
dc.subject | 3 &apos | - |
dc.subject | dG(6)-run | - |
dc.subject | phosphodiester | - |
dc.subject | T(H)1 | - |
dc.subject | immune modulation | - |
dc.subject | IMMUNOSTIMULATORY DNA-SEQUENCES | - |
dc.subject | CD8 T-CELLS | - |
dc.subject | BACTERIAL-DNA | - |
dc.subject | PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | - |
dc.subject | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject | INFLAMMATION | - |
dc.subject | MOTIFS | - |
dc.subject | MURINE | - |
dc.subject | MICE | - |
dc.subject | EOSINOPHILIA | - |
dc.title | The enhanced effect of a hexameric deoxyriboguanosine run conjugation to CpG oligodeoxynucleotides on protection against allergic asthma | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1067/mai.2001.118517 | - |
dc.author.google | Park, Y | - |
dc.author.google | Chang, YS | - |
dc.author.google | Lee, SW | - |
dc.author.google | Cho, SY | - |
dc.author.google | Kim, YK | - |
dc.author.google | Min, KU | - |
dc.author.google | Kim, YY | - |
dc.author.google | Cho, SH | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 108 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 570 | - |
dc.relation.lastpage | 576 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, v.108, no.4, pp.570 - 576 | - |
dc.identifier.wosid | 000171760300016 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 576 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 570 | - |
dc.citation.title | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | - |
dc.citation.volume | 108 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0034780187 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 27 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IMMUNOSTIMULATORY DNA-SEQUENCES | - |
dc.subject.keywordPlus | CD8 T-CELLS | - |
dc.subject.keywordPlus | BACTERIAL-DNA | - |
dc.subject.keywordPlus | PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDES | - |
dc.subject.keywordPlus | AIRWAY HYPERRESPONSIVENESS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MOTIFS | - |
dc.subject.keywordPlus | MURINE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | EOSINOPHILIA | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | CpG oligodeoxynucleotides | - |
dc.subject.keywordAuthor | 3 &apos | - |
dc.subject.keywordAuthor | dG(6)-run | - |
dc.subject.keywordAuthor | phosphodiester | - |
dc.subject.keywordAuthor | T(H)1 | - |
dc.subject.keywordAuthor | immune modulation | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
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