DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, JW | - |
dc.contributor.author | Baek, WK | - |
dc.contributor.author | Suh, SI | - |
dc.contributor.author | Yang, SH | - |
dc.contributor.author | Chang, J | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Suh, MH | - |
dc.date.accessioned | 2016-03-31T13:19:12Z | - |
dc.date.available | 2016-03-31T13:19:12Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2001-04 | - |
dc.identifier.issn | 0106-9543 | - |
dc.identifier.other | 2001-OAK-0000001968 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19560 | - |
dc.description.abstract | Aims/Background: The hepatitis C virus (HCV) core protein is known to Flay an important role in hepatocarcinogenesis. Recent studies have suggested that the increased proliferation rate of hepatocytes is a major risk factor for the development of hepatocellular carcinoma. In this study, we investigated whether the HCV core protein promotes the cell growth rate through the modulation of cyclin E expression levels. Methods/Results: HCV core stable transfectant Rat-1 cell lines showed a markedly increased proliferation rate compared to mock cells. Cyclin E expression and its associated kinase activities were remarkably increased in HCV core stable transfect;mts, Cyclin E mRNA levels were also upregulated in these eel lines. Conclusions: Our data suggest that the HCV core protein promotes cell proliferation through upregulation of the cyclin E expression levels, implying this property of HCV core protein plays an important role in hepatocarcinogenesis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | MUNKSGAARD INT PUBL LTD | - |
dc.relation.isPartOf | LIVER | - |
dc.subject | hepatitis C virus | - |
dc.subject | core protein | - |
dc.subject | cyclin E | - |
dc.subject | hepatocarcinogenesis | - |
dc.subject | RAT EMBRYO FIBROBLASTS | - |
dc.subject | BREAST-CANCER | - |
dc.subject | G(1) | - |
dc.subject | G(1)-CYCLINS | - |
dc.subject | ACCELERATION | - |
dc.title | Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1034/j.1600-0676.2001.021002137.x | - |
dc.author.google | Cho, JW | - |
dc.author.google | Baek, WK | - |
dc.author.google | Suh, SI | - |
dc.author.google | Yang, SH | - |
dc.author.google | Chang, J | - |
dc.author.google | Sung, YC | - |
dc.author.google | Suh, MH | - |
dc.relation.volume | 21 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 137 | - |
dc.relation.lastpage | 142 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | LIVER | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | LIVER, v.21, no.2, pp.137 - 142 | - |
dc.identifier.wosid | 000168457000009 | - |
dc.date.tcdate | 2018-10-01 | - |
dc.citation.endPage | 142 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 137 | - |
dc.citation.title | LIVER | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-0035042905 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 40 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RAT EMBRYO FIBROBLASTS | - |
dc.subject.keywordPlus | G(1) | - |
dc.subject.keywordPlus | ACCELERATION | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | core protein | - |
dc.subject.keywordAuthor | cyclin E | - |
dc.subject.keywordAuthor | hepatocarcinogenesis | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
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