An efficient and practical method for the synthesis of mono-N-protected alpha,omega-diaminoalkanes

Abstract

The large-scale synthesis of mono-N-protected (Cbz, Boc, Ts, and Ns) alpha,omega -diaminoalkanes (the number of carbon atoms = 3, 4, 5 and 6) are accomplished in 81-945 yield by the protection of amine and subsequent reduction of an azido group from alpha,omega -azido alkyl amines. alpha,omega -Azido alkyl amines are prepared efficiently by the partial reduction of alpha,omega -diazidoalkanes which are obtained from the corresponding dibromoalkanes. (C) 2001 Elsevier Science Ltd. All rights reserved.