DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Oh, YS | - |
dc.contributor.author | Perry, DK | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T13:21:41Z | - |
dc.date.available | 2016-03-31T13:21:41Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2001-02-23 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.other | 2001-OAK-0000001833 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19652 | - |
dc.description.abstract | Apoptotic proteases cleave and inactivate survival signaling molecules such as Akt/PKB, phospholipase C (PLC)-gamma1, and Bcl-2. We have found that treatment of A431 cells with tumor necrosis factor-alpha in the presence of cycloheximide resulted in the cleavage of epidermal growth factor receptor (EGFR) as well as the activation of caspase-3. Among various caspases, caspase-1, caspase-3 and caspase-7 were most potent in the cleavage of EGFR in vitro. Proteolytic cleavage of EGFR was inhibited by both YVAD-cmk and DEVD-fmk in vitro. We also investigated the effect of caspase-dependent cleavage of EGFR upon the mediation of signals to downstream signaling molecules such as PLC-gamma1. Cleavage of EGFR by caspase-3 significantly impaired the tyrosine phosphorylation of PLC-gamma1 in vitro. Given these results, we suggest that apoptotic protease specifically cleaves and inactivates EGFR, which plays crucial roles in anti-apoptotic signaling, to abrogate the activation of EGFR-dependent downstream survival signaling molecules, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.subject | apoptosis | - |
dc.subject | proteolysis | - |
dc.subject | receptor | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | EGF RECEPTOR | - |
dc.subject | DEATH | - |
dc.subject | APOPTOSIS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PROTEASE | - |
dc.subject | ACTIVATION | - |
dc.subject | SIGNALS | - |
dc.subject | BCL-2 | - |
dc.subject | SITE | - |
dc.title | Proteolytic cleavage of epidermal growth factor receptor by caspases | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/S0014-5793(01)02167-6 | - |
dc.author.google | Bae, SS | - |
dc.author.google | Choi, JH | - |
dc.author.google | Oh, YS | - |
dc.author.google | Perry, DK | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 491 | - |
dc.relation.issue | 1-2 | - |
dc.relation.startpage | 16 | - |
dc.relation.lastpage | 20 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | FEBS LETTERS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.491, no.1-2, pp.16 - 20 | - |
dc.identifier.wosid | 000167248400004 | - |
dc.date.tcdate | 2018-12-01 | - |
dc.citation.endPage | 20 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 16 | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 491 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0035936892 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 33 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | EGF RECEPTOR | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PROTEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SIGNALS | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordPlus | SITE | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | proteolysis | - |
dc.subject.keywordAuthor | receptor | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
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