Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages
SCIE
SCOPUS
- Title
- Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages
- Authors
- Lee, CH; Choi, YH; Yang, SH; Lee, CW; Ha, SJ; Sung, YC
- Date Issued
- 2001-01-05
- Publisher
- ACADEMIC PRESS INC
- Abstract
- A characteristic feature of hepatitis C virus (HCV) infection is a high frequency of persistence and the progression to chronic liver diseases. Recent data suggest that prevalent T helper (Th) 2 immunity as well as weak HCV-specific T-cell response is associated with viral persistence. Here, we showed that the production of interleukin 12 (IL-12) and nitric oxide (NO) that is critical for the induction of Th1 and innate immunity, but not that of tumor necrosis factor alpha (TNF-alpha), was significantly suppressed in both HCV core-expressing macrophage cell lines and mouse peritoneal macrophages treated with recombinant core protein. in addition, IL-12 p40 promoter activity was repressed by the presence of HCV core in macrophages stimulated with lipopolysaccharride (LPS) following IFN-gamma treatment, indicating that IL-12 production may be downregulated at the transcriptional level. We also found that proliferation of T cells and IFN-gamma , production in mixed lymphocyte reactions (MLR) with core-expressing cells were inhibited. Taken together, our results suggest that HCV core protein could play roles in suppressing the induction of Th1 immunity through inhibition of IL-12 and NO production. (C) 2001 Academic Press.
- Keywords
- BLOOD MONONUCLEAR-CELLS; T-HELPER CELLS; DENDRITIC CELLS; HEMATOPOIETIC-CELLS; IL-12 PRODUCTION; IMMUNE-RESPONSE; IN-VIVO; INFECTION; KINASE; INTERFERON
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19711
- DOI
- 10.1006/viro.2000.0694
- ISSN
- 0042-6822
- Article Type
- Article
- Citation
- VIROLOGY, vol. 279, no. 1, page. 271 - 279, 2001-01-05
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- There are no files associated with this item.
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