DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, SY | - |
dc.contributor.author | Ha, H | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T13:27:02Z | - |
dc.date.available | 2016-03-31T13:27:02Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2000-10-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2000-OAK-0000001552 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/19852 | - |
dc.description.abstract | Platelet-activating factor (PAF) is an important participant in the inflammatory process. We studied the regulation of PAF activity by capsaicin in human promyelocytic leukemia HL-60 cells. Capsaicin inhibited PAF-induced superoxide production in a concentration-dependent manner. In addition to PAF, the fMLP- and extracellular ATP-induced superoxide productions were inhibited by capsaicin, whereas PMA-induced superoxide production was not affected. In the PAF-stimulated cytosolic Ca2+ increase, capsaicin inhibited in particular the sustained portion of the raised Ca2+ level without attenuation of the peak height. In the absence of extracellular Ca2+, the PAF-induced Ca2+ elevation was not inhibited by capsaicin because capsaicin only inhibited the Ca2+ influx from the extracellular space. In addition, capsaicin did not affect PAF-induced inositol 1,4,5-trisphosphate production, suggesting that phospholipase C activation by PAF is not affected by capsaicin. Store-operated Ca2+ entry (SOCE) induced by thapsigargin was inhibited by capsaicin in a concentration-dependent manner. This capsaicin effect was also observed on thapsigargin-induced Ba2+ and Mn2+ influx. Furthermore, capsaicin's inhibitory effect on the thapsigargin-induced Ca2+ rise overlapped with that of SK&F96365, an inhibitor of SOCE. Both capsaicin and SK&F96365 also inhibited PAF-induced cytosolic superoxide generation in HL-60 cells differentiated by all-trans-retinoic acid. Our data suggest that capsaicin exerts its anti-inflammatory effect by inhibiting SOCE elicited via PLC activation, which occurs upon PAF activation and results in the subsequent superoxide production. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | MEDIATED CALCIUM-ENTRY | - |
dc.subject | PROTEIN-KINASE-A | - |
dc.subject | HL-60 CELLS | - |
dc.subject | HUMAN NEUTROPHILS | - |
dc.subject | SUBSTANCE-P | - |
dc.subject | GRANULOCYTIC DIFFERENTIATION | - |
dc.subject | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject | RECEPTOR ANTAGONIST | - |
dc.subject | RESPIRATORY BURST | - |
dc.subject | GANGLION NEURONS | - |
dc.title | Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.165.7.3992 | - |
dc.author.google | Choi, SY | - |
dc.author.google | Ha, H | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 165 | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 3992 | - |
dc.relation.lastpage | 3998 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.165, no.7, pp.3992 - 3998 | - |
dc.identifier.wosid | 000089477500058 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 3998 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3992 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 165 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0034292420 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MEDIATED CALCIUM-ENTRY | - |
dc.subject.keywordPlus | PROTEIN-KINASE-A | - |
dc.subject.keywordPlus | HL-60 CELLS | - |
dc.subject.keywordPlus | HUMAN NEUTROPHILS | - |
dc.subject.keywordPlus | SUBSTANCE-P | - |
dc.subject.keywordPlus | GRANULOCYTIC DIFFERENTIATION | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject.keywordPlus | RECEPTOR ANTAGONIST | - |
dc.subject.keywordPlus | RESPIRATORY BURST | - |
dc.subject.keywordPlus | GANGLION NEURONS | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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