Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
SCIE
SCOPUS
- Title
- Interleukin-6-induced tyrosine phosphorylation of phospholipase C-gamma 1 in PC12 cells
- Authors
- Lee, YH; Bae, SS; Seo, JK; Choi, I; Ryu, SH; Suh, PG
- Date Issued
- 2000-08-31
- Publisher
- SPRINGER-VERLAG SINGAPORE PTE LTD
- Abstract
- Phospholipase C (PLC)-gamma 1 plays a pivotal role in the signal transduction pathway mediated by growth factors. In this study, we found that neurite outgrowth of pheochromocytoma (PC12) cells was significantly induced by interleukin-6 (IL-6). Stimulation of PC12 cells with IL-6 led to tyrosine phosphorylation of PLC-gamma 1 in a dose- and time-dependent manner. IL-6 stimulation also increased the hydrolysis of phosphatidylinositol 4,5-bisphosphate. Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma 1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine, These results suggest-that PLC-gamma 1 may be involved in the signal transduction pathway of IL-6-induced PC12 cell differentiation.
- Keywords
- interleukin-6; PC12 cells; phospholipase C-gamma 1; signal transduction; tyrosine phosphorylation; NERVE GROWTH-FACTOR; LEUKEMIA INHIBITORY FACTOR; SIGNAL TRANSDUCER GP130; CYTOKINE RECEPTORS; NEURITE OUTGROWTH; MESSENGER-RNA; C-GAMMA; ACTIVATION; KINASES; DIFFERENTIATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/19881
- ISSN
- 1016-8478
- Article Type
- Article
- Citation
- MOLECULES AND CELLS, vol. 10, no. 4, page. 469 - 474, 2000-08-31
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- There are no files associated with this item.
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