DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, MJ | - |
dc.contributor.author | Si, F | - |
dc.contributor.author | Kim, SJ | - |
dc.contributor.author | Hong, SB | - |
dc.contributor.author | Hwang, JI | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Chang, JS | - |
dc.contributor.author | Lee, YH | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T13:35:20Z | - |
dc.date.available | 2016-03-31T13:35:20Z | - |
dc.date.created | 2009-08-12 | - |
dc.date.issued | 1999-12-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2000-OAK-0000001098 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20162 | - |
dc.description.abstract | Phospholipase C-gamma 1 (PLC-gamma 1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG, By using the yeast two-hybrid system, we identified the translational elongation factor-1 alpha (EF-1 alpha) as a binding protein of PLC-gamma 1 from the human B-lymphocyte library, Direct interaction between EF-1 alpha and PLC-gamma 1 was confirmed by the in vitro binding experiment using purified PLC-gamma 1, Furthermore, from the in vitro binding experiment, we could demonstrate that the carboxyl terminal region of EF-1 alpha is involved in the interaction with PLC-gamma 1, and that both SH2 and SH3 domains of PLC-gamma 1 are required for the interaction with EF-1 alpha. In vivo interaction between EF-1 alpha and PLC-gamma 1 was confirmed by the immunoprecipitation experiment using anti-EF-1 alpha antibody. The interaction between EF-1 alpha and PLC-gamma 1 was enhanced by EGF-treatment, Taken together, we suggest that EF-1 alpha might play a role in PLC-gamma 1-mediated signal transduction. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | EF-1 alpha | - |
dc.subject | PLC-gamma 1 | - |
dc.subject | src homology domain | - |
dc.subject | yeast two hybrid system | - |
dc.subject | FACTOR EF-1-ALPHA | - |
dc.subject | TYROSINE KINASE | - |
dc.subject | FACTOR 1-ALPHA | - |
dc.subject | C ISOZYMES | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | TRANSFORMATION | - |
dc.subject | HOMOLOGY | - |
dc.subject | DICTYOSTELIUM | - |
dc.subject | SEQUENCE | - |
dc.title | The SH2-SH2-SH3 domain of phospholipase C-gamma 1 directly binds to translational elongation factor-1 alpha | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Kim, MJ | - |
dc.author.google | Si, F | - |
dc.author.google | Kim, SJ | - |
dc.author.google | Hong, SB | - |
dc.author.google | Hwang, JI | - |
dc.author.google | Lee, HJ | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Chang, JS | - |
dc.author.google | Lee, YH | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 631 | - |
dc.relation.lastpage | 637 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.9, no.6, pp.631 - 637 | - |
dc.identifier.wosid | 000084460500009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 637 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 631 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0033621283 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | FACTOR EF-1-ALPHA | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | FACTOR 1-ALPHA | - |
dc.subject.keywordPlus | C ISOZYMES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSFORMATION | - |
dc.subject.keywordPlus | HOMOLOGY | - |
dc.subject.keywordPlus | DICTYOSTELIUM | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordAuthor | EF-1 alpha | - |
dc.subject.keywordAuthor | PLC-gamma 1 | - |
dc.subject.keywordAuthor | src homology domain | - |
dc.subject.keywordAuthor | yeast two hybrid system | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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