DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, SS | - |
dc.contributor.author | Shin, HC | - |
dc.contributor.author | Choi, KY | - |
dc.contributor.author | Oh, BH | - |
dc.date.accessioned | 2016-03-31T13:41:56Z | - |
dc.date.available | 2016-03-31T13:41:56Z | - |
dc.date.created | 2009-03-17 | - |
dc.date.issued | 1999-05 | - |
dc.identifier.issn | 0907-4449 | - |
dc.identifier.other | 1999-OAK-0000000745 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20407 | - |
dc.description.abstract | TRAIL (also known as Apo-2L) belongs to the tumour necrosis factor (TNF) cytokine family and induces rapid apoptosis in a wide variety of tumour cell lines upon binding to the death-signalling receptors on the cell membrane. Normal cells are resistant to TRAIL, owing to the expression of decoy receptors which lack functional death domains and antagonize TRAIL-induced apoptosis. Soluble and functional human TRAIL, expressed in Escherichia coli and refolded into a functional form, has been crystallized. The crystals belong to space group P6(3) with unit-cell dimensions a = b = 65.61, c = 131.70 Angstrom. The asymmetric unit contains two molecules of TRAIL, with a crystal volume per protein mass (V-m) of 2.41 Angstrom(3) Da(-1) and a solvent content of about 42% by volume. A native and a platinum-derivative data set to 2.8 and 3.5 Angstrom resolution, respectively, were obtained from frozen crystals. Structure determination by a combined molecular replacement and isomorphous replacement method is in progress. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | MUNKSGAARD INT PUBL LTD | - |
dc.relation.isPartOf | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | TNF RECEPTOR SUPERFAMILY | - |
dc.subject | INDUCED CELL-DEATH | - |
dc.subject | FACTOR-ALPHA | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | MUTATIONAL ANALYSIS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | LIGAND | - |
dc.subject | FAMILY | - |
dc.subject | DOMAIN | - |
dc.title | Expression, purification and crystallization of recombinant human TRAIL | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1107/S090744499900164X | - |
dc.author.google | Cha, SS | - |
dc.author.google | Shin, HC | - |
dc.author.google | Choi, KY | - |
dc.author.google | Oh, BH | - |
dc.relation.volume | 55 | - |
dc.relation.startpage | 1101 | - |
dc.relation.lastpage | 1104 | - |
dc.contributor.id | 10052985 | - |
dc.relation.journal | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, v.55, pp.1101 - 1104 | - |
dc.identifier.wosid | 000080399700030 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1104 | - |
dc.citation.startPage | 1101 | - |
dc.citation.title | ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | - |
dc.citation.volume | 55 | - |
dc.contributor.affiliatedAuthor | Choi, KY | - |
dc.contributor.affiliatedAuthor | Oh, BH | - |
dc.identifier.scopusid | 2-s2.0-0033135957 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | TNF RECEPTOR SUPERFAMILY | - |
dc.subject.keywordPlus | INDUCED CELL-DEATH | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | MUTATIONAL ANALYSIS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Crystallography | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Crystallography | - |
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