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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, MJ | - |
| dc.contributor.author | Hwang, JI | - |
| dc.contributor.author | Chang, JS | - |
| dc.contributor.author | Ryu, SH | - |
| dc.contributor.author | Suh, PG | - |
| dc.date.accessioned | 2016-03-31T13:43:29Z | - |
| dc.date.available | 2016-03-31T13:43:29Z | - |
| dc.date.created | 2009-08-12 | - |
| dc.date.issued | 1999-03-31 | - |
| dc.identifier.issn | 1225-8687 | - |
| dc.identifier.other | 1999-OAK-0000000666 | - |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20462 | - |
| dc.description.abstract | The Shc3 domain of PLC-gamma 1 has been known to induce DNA synthesis. However, little is known about the putative effector proteins that associate with the domain, In this report, we provide evidence that the SH3 domain of PLC-gamma 1 associates with Shc, which has been implicated in the activation of p21Ras in response to many growth factors. The association between Shc and PLC-gamma 1 is enhanced either by nu-Src-induced transformation or EGF-stimulation in vivo and in vitro. Furthermore, from transient expression studies with COS-7 cells, we show that the SH3 domain of PLC-gamma 1 is required for association with Shc in vivo, whereas tyrosyl phosphorylation of PLC-gamma 1 is not. Taken together, we suggest that Shc might be involved in the PLC-gamma 1-mediated signaling pathway. | - |
| dc.description.statementofresponsibility | X | - |
| dc.language | English | - |
| dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
| dc.relation.isPartOf | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
| dc.subject | GST | - |
| dc.subject | PLC-gamma 1 | - |
| dc.subject | protein-protein interaction | - |
| dc.subject | SH3 domain | - |
| dc.subject | Shc | - |
| dc.subject | DNA-SYNTHESIS | - |
| dc.subject | ELEVATED CONTENT | - |
| dc.subject | B-LYMPHOCYTES | - |
| dc.subject | C ISOZYMES | - |
| dc.subject | PROTEIN | - |
| dc.subject | PLC-GAMMA-1 | - |
| dc.subject | HOMOLOGY | - |
| dc.subject | RAS | - |
| dc.subject | SRC | - |
| dc.subject | PHOSPHORYLATION | - |
| dc.title | The SH3 domain of phospholipase C-gamma 1 associates with Shc | - |
| dc.type | Article | - |
| dc.contributor.college | 생명과학과 | - |
| dc.author.google | Kim, MJ | - |
| dc.author.google | Hwang, JI | - |
| dc.author.google | Chang, JS | - |
| dc.author.google | Ryu, SH | - |
| dc.author.google | Suh, PG | - |
| dc.relation.volume | 32 | - |
| dc.relation.issue | 2 | - |
| dc.relation.startpage | 119 | - |
| dc.relation.lastpage | 126 | - |
| dc.contributor.id | 10052640 | - |
| dc.relation.journal | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
| dc.relation.index | SCI급, SCOPUS 등재논문 | - |
| dc.relation.sci | SCIE | - |
| dc.collections.name | Journal Papers | - |
| dc.type.rims | ART | - |
| dc.identifier.bibliographicCitation | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.32, no.2, pp.119 - 126 | - |
| dc.identifier.wosid | 000079316600003 | - |
| dc.date.tcdate | 2019-01-01 | - |
| dc.citation.endPage | 126 | - |
| dc.citation.number | 2 | - |
| dc.citation.startPage | 119 | - |
| dc.citation.title | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
| dc.citation.volume | 32 | - |
| dc.contributor.affiliatedAuthor | Ryu, SH | - |
| dc.contributor.affiliatedAuthor | Suh, PG | - |
| dc.identifier.scopusid | 2-s2.0-0347512495 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalClass | 1 | - |
| dc.description.wostc | 10 | - |
| dc.type.docType | Article | - |
| dc.subject.keywordPlus | DNA-SYNTHESIS | - |
| dc.subject.keywordPlus | ELEVATED CONTENT | - |
| dc.subject.keywordPlus | B-LYMPHOCYTES | - |
| dc.subject.keywordPlus | C ISOZYMES | - |
| dc.subject.keywordPlus | PROTEIN | - |
| dc.subject.keywordPlus | PLC-GAMMA-1 | - |
| dc.subject.keywordPlus | HOMOLOGY | - |
| dc.subject.keywordPlus | RAS | - |
| dc.subject.keywordPlus | SRC | - |
| dc.subject.keywordPlus | PHOSPHORYLATION | - |
| dc.subject.keywordAuthor | GST | - |
| dc.subject.keywordAuthor | PLC-gamma 1 | - |
| dc.subject.keywordAuthor | protein-protein interaction | - |
| dc.subject.keywordAuthor | SH3 domain | - |
| dc.subject.keywordAuthor | Shc | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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- 류성호RYU, SUNG HO
- Dept of Life Sciences