DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, YS | - |
dc.contributor.author | Ju, SA | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Seo, JK | - |
dc.contributor.author | Baek, SH | - |
dc.contributor.author | Kwak, JY | - |
dc.contributor.author | Kim, BS | - |
dc.contributor.author | Suh, PG | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-03-31T13:44:51Z | - |
dc.date.available | 2016-03-31T13:44:51Z | - |
dc.date.created | 2009-08-12 | - |
dc.date.issued | 1999-02 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.other | 1999-OAK-0000000596 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/20512 | - |
dc.description.abstract | Among the phagocytic leukocytes, monocytes have the important role of clearing out parasitic microorganisms, They accomplish this through production of toxic metabolites of oxygen, Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), a peptide that stimulates phosphoinositide (PI) hydrolysis in human leukocytes, including monocytes, binds to a unique cell surface receptor and stimulates superoxide generation, killing of Staphylococcus aureus, and activation of phospholipase D (PLD) in human monocytes. Preincubation of the cells with a PI-specific phospholipase C (PLC) inhibitor (U-73122), protein kinase C inhibitor (GF109203X), or intracellular Ca2+ chelator (BAPTA/AM) before the peptide stimulus totally inhibits the peptide-induced PLD activation and superoxide generation. On the other baud, tyrosine kinase inhibitor genistein only partially inhibits the peptide-induced processes, The peptide-induced bacteria killing activity shares regulatory mechanisms for PLD activation with the superoxide generation, which is inhibited in the presence of l-butanol, We suggest that the peptide stimulates PLD downstream of PLC activation and PLD activation in turn is essential for the peptide-induced immunological functions such as the superoxide generation and killing of bacteria by human monocytes. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.relation.isPartOf | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.subject | signal transduction | - |
dc.subject | immunomodulators | - |
dc.subject | lipid mediators | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | HUMAN NEUTROPHILS | - |
dc.subject | RESPIRATORY BURST | - |
dc.subject | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject | PHOSPHATIDIC-ACID | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | NADPH OXIDASE | - |
dc.subject | HL-60 CELLS | - |
dc.subject | RECEPTOR | - |
dc.subject | MECHANISMS | - |
dc.title | Trp-Lys-Tyr-Met-Val-D-Met stimulates superoxide generation and killing of Staphylococcus aureus via phospholipase D activation in human monocytes | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1002/jlb.65.2.241 | - |
dc.author.google | Bae, YS | - |
dc.author.google | Ju, SA | - |
dc.author.google | Kim, JY | - |
dc.author.google | Seo, JK | - |
dc.author.google | Baek, SH | - |
dc.author.google | Kwak, JY | - |
dc.author.google | Kim, BS | - |
dc.author.google | Suh, PG | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 65 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 241 | - |
dc.relation.lastpage | 248 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.65, no.2, pp.241 - 248 | - |
dc.identifier.wosid | 000078390200012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 248 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 241 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 65 | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-0033047887 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 46 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | HUMAN NEUTROPHILS | - |
dc.subject.keywordPlus | RESPIRATORY BURST | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE HYDROLYSIS | - |
dc.subject.keywordPlus | PHOSPHATIDIC-ACID | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | NADPH OXIDASE | - |
dc.subject.keywordPlus | HL-60 CELLS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | signal transduction | - |
dc.subject.keywordAuthor | immunomodulators | - |
dc.subject.keywordAuthor | lipid mediators | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
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