DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gho, YS | - |
dc.contributor.author | Chae, CB | - |
dc.date.accessioned | 2016-03-31T14:04:13Z | - |
dc.date.available | 2016-03-31T14:04:13Z | - |
dc.date.created | 2013-11-04 | - |
dc.date.issued | 1999-02-28 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 1999-OAK-0000010141 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21093 | - |
dc.description.abstract | Human prostate and breast tumor cells produce luteinizing hormone-releasing hormone (LHRH) receptors on their cell surface even when they have lost dependency on sex steroid hormones for growth. To investigate whether LHRH can be used as a cell-binding moiety to deliver toxin molecules into prostate and breast tumor cells, LHRH-bovine RNase A conjugates were constructed using the chemical crosslinking method. The treatment of the LHRH receptor-positive cells such as prostate LNCapFGC and breast MCF7 tumor cells with LHRH-RNase A conjugates resulted in a dose-dependent inhibition of growth. The cytotoxic activities of these conjugates were effectively reduced by the presence of exogenous LHRH. Either free RNase A or LHRH alone did not affect the proliferation of these cells. The LHRH-RNase A conjugates did not show cytotoxicity against FRTL5 and TM4 cells which do not express the LHRH receptors, These results suggest that LHRH can be used as a cell-binding molecule for the specific delivery of toxin molecules into the cells which express LHRH receptors on their surface. Thus, a new class of biomedicines that act as fusion proteins between LHRH and toxins will give us a new avenue for the treatment of human prostate and breast cancers, regardless of their steroid hormone dependency. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | breast | - |
dc.subject | LHRH | - |
dc.subject | prostate | - |
dc.subject | RNase A | - |
dc.subject | tumor | - |
dc.subject | PSEUDOMONAS EXOTOXIN | - |
dc.subject | CANCER-CELLS | - |
dc.subject | GROWTH | - |
dc.subject | IMMUNOTOXINS | - |
dc.subject | RIBONUCLEASE | - |
dc.subject | PROTEINS | - |
dc.subject | ANALOGS | - |
dc.subject | THERAPY | - |
dc.subject | AGONIST | - |
dc.subject | RAT | - |
dc.title | Luteinizing hormone releasing hormone-RNase A conjugates specifically inhibit the proliferation of LHRH-receptor-positive human prostate and breast tumor cells | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Gho, YS | - |
dc.author.google | Chae, CB | - |
dc.relation.volume | 9 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 31 | - |
dc.relation.lastpage | 36 | - |
dc.contributor.id | 10138843 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.9, no.1, pp.31 - 36 | - |
dc.identifier.wosid | 000078881400006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 9 | - |
dc.contributor.affiliatedAuthor | Gho, YS | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PSEUDOMONAS EXOTOXIN | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | IMMUNOTOXINS | - |
dc.subject.keywordPlus | RIBONUCLEASE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | AGONIST | - |
dc.subject.keywordPlus | RAT | - |
dc.subject.keywordAuthor | breast | - |
dc.subject.keywordAuthor | LHRH | - |
dc.subject.keywordAuthor | prostate | - |
dc.subject.keywordAuthor | RNase A | - |
dc.subject.keywordAuthor | tumor | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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