DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, KM | - |
dc.contributor.author | Song, OK | - |
dc.contributor.author | Jang, SK | - |
dc.date.accessioned | 2016-03-31T14:07:17Z | - |
dc.date.available | 2016-03-31T14:07:17Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 1997-10-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 1997-OAK-0000009958 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21186 | - |
dc.description.abstract | Hepatitis C virus (HCV), a major etiologic agent of transfusion associated hepatitis, is a positive, single-stranded RNA virus and is also known to be implicated in liver cirrhosis and hepatocellular carcinoma. Nonstructural protein 5A (NS5A) of HCV contains acidic and proline-rich amino acids in its carboxy-terminal half. These structural features resemble eukaryotic transcription activators. In this report, we show that NS5A functions as a potent transcriptional activator when fused to the yeast (Saccharomyces cerevisiae) GAL4 DNA-binding domain (1-147). The potential transcriptional activator maps to the C-terminal half of NS5A in the yeast cell. Therefore, our data provides the first evidence that NS5A may modulate host cell function at the transcriptional level. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MOLECULAR BIOLOGY | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | NON-B-HEPATITIS | - |
dc.subject | SERINE PROTEINASE | - |
dc.subject | DNA-BINDING | - |
dc.subject | NON-A | - |
dc.subject | HEPATOCELLULAR-CARCINOMA | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | NS5A REGION | - |
dc.subject | YEAST | - |
dc.subject | NS3 | - |
dc.subject | POLYPROTEIN | - |
dc.title | Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Chung, KM | - |
dc.author.google | Song, OK | - |
dc.author.google | Jang, SK | - |
dc.relation.volume | 7 | - |
dc.relation.issue | 5 | - |
dc.relation.startpage | 661 | - |
dc.relation.lastpage | 667 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.7, no.5, pp.661 - 667 | - |
dc.identifier.wosid | A1997YD55800015 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 667 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 661 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.identifier.scopusid | 2-s2.0-0031592827 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 38 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NON-B-HEPATITIS | - |
dc.subject.keywordPlus | SERINE PROTEINASE | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | NON-A | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NS5A REGION | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | NS3 | - |
dc.subject.keywordPlus | POLYPROTEIN | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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