Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
SCIE
SCOPUS
- Title
- Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
- Authors
- Kim, D; Jun, KS; Lee, SB; Kang, NG; Min, DS; Kim, YH; Ryu, SH; Suh, PG; Shin, HS
- Date Issued
- 1997-09-18
- Publisher
- MACMILLAN MAGAZINES LTD
- Abstract
- A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins'. There are four isoenzymes of PLC-beta, beta 1-beta 4, but their functions in vivo are not known. Here we investigate the role of PLC-beta 1 and PLC-beta 4 in the brain by generating-null mutations in mice: we found that PLC beta 1(-/-) mice developed epilepsy and PLC beta 4(-/-) mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta 1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling pre-dominantly to the muscarinic acetylcholine receptor, whereas PLC-beta 4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain.
- Keywords
- PHOSPHOINOSITIDE HYDROLYSIS; SIGNAL-TRANSDUCTION; ALZHEIMERS-DISEASE; MESSENGER-RNAS; RAT-BRAIN; EPILEPSY; SEIZURES; MICE; LOCALIZATION; INTERNEURONS
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21228
- DOI
- 10.1038/38508
- ISSN
- 0028-0836
- Article Type
- Article
- Citation
- NATURE, vol. 389, no. 6648, page. 290 - 293, 1997-09-18
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- There are no files associated with this item.
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