DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Bahk, YY | - |
dc.contributor.author | Yun, DH | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Lee, YH | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-03-31T14:11:49Z | - |
dc.date.available | 2016-03-31T14:11:49Z | - |
dc.date.created | 2009-08-12 | - |
dc.date.issued | 1997-04 | - |
dc.identifier.issn | 1044-5498 | - |
dc.identifier.other | 1997-OAK-0000009764 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21318 | - |
dc.description.abstract | We have cloned and characterized a genomic DNA spanning the 5'-flanking region, the first and second exons, and the first intron of the human PLC-gamma 2 gene. The proximal upstream region is highly CC-rich and lacks a TATA box, whereas the distal region contains several AT-rich tracts. Multiple transcription initiation sites were identified by primer extension analysis, Based on the transient transfection assays, the major transcriptional activation element was identified between -183 and +43 (G2SE) and a transcriptional repressive element was found between -303 and -184 (G2RE). The expression of PLC-gamma 2 in various cell lines was examined using monoclonal anti-PLC-gamma 2 antibody, PLC-gamma 2 was highly expressed in B-cell lines such as Daudi, SP2, and Ramos cells, whereas it existed at very low levels in Jurkat, 3T3-L1, NBL-7, and C6Bu-1 cells. Moderate levels of PLC-gamma 2 were also detected in C2C12, P19, U937, HL60, A431, and PC12 cells. The 4-kb genomic fragment upstream of -1,654 was able to activate transcription from the PLC-gamma 2 promoter in Daudi and C2C12 cells, but not in Jurkat cells, which is consistent with the PLC-gamma 2 protein expression levels in those cell lines. These results suggest that the cell-type-specific expression of PLC-gamma 2 might be attributed to the transcriptional regulation by the upstream cis-element. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | MARY ANN LIEBERT INC PUBL | - |
dc.relation.isPartOf | DNA AND CELL BIOLOGY | - |
dc.title | The promoter activity of the phospholipase C-gamma 2 gene is regulated by a cell-type-specific control element | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1089/dna.1997.16.485 | - |
dc.author.google | Lee, SJ | - |
dc.author.google | Bahk, YY | - |
dc.author.google | Yun, DH | - |
dc.author.google | Lee, HJ | - |
dc.author.google | Lee, YH | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 16 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 485 | - |
dc.relation.lastpage | 492 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | DNA AND CELL BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | DNA AND CELL BIOLOGY, v.16, no.4, pp.485 - 492 | - |
dc.identifier.wosid | A1997WY50500012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 492 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 485 | - |
dc.citation.title | DNA AND CELL BIOLOGY | - |
dc.citation.volume | 16 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-0030965863 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MURINE LYMPHOCYTES-B | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | ELEVATED CONTENT | - |
dc.subject.keywordPlus | C ISOZYMES | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
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