DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suh, BC | - |
dc.contributor.author | Song, SK | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-03-31T14:15:28Z | - |
dc.date.available | 2016-03-31T14:15:28Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 1996-12-20 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | 1997-OAK-0000009621 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/21422 | - |
dc.description.abstract | Mas-7, a mastoparan derivative, induces elevation of intracellular free Ca2+ concentration ([Ca2+](i)) along two independent pathways. The minor contribution occurs via phospholipase C activation and is negatively regulated by treatment with phorbol 12-myristate 13-acetate, a protein kinase C activator. The major contribution involves plasma membrane pores allowing not only Ca2+, Mn2+, and Na+ to enter but also the uptake of ethidium bromide (314 Pa) and lucifer yellow (457 Da), but not fura-2 (831 Pa), Evans blue (961 Pa), and fluorescein-conjugate phalloidin (1,175 Da). Mas-7-induced current, as measured in planar lipid bilayers, reveals that Mas-7-induced pores have two slope conductances, 290 and 94 pS, and that the pores are nonselective for cations. The results also indicate that Mas-7 can produce pores by direct interaction with the plasma membrane without the involvement of membrane proteins and cytosolic factors. Besides in human neuroblastoma cells, similar Mas-7 effects were also observed in other cell lines such as HL-60, 1321N1 human astrocytoma, and bovine chromaffin cells. The data suggest that the Mas 7-induced [Ca2+](i) elevation is the combined result of Ca2+ release from stores via phosphoinositide turnover and prolonged Ca2+ influx through membrane pores. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLO | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.subject | NUCLEOSIDE DIPHOSPHATE KINASE | - |
dc.subject | GTP-BINDING PROTEINS | - |
dc.subject | NEUROBLASTOMA SK-N-BE(2)C CELLS | - |
dc.subject | FURA-2-LOADED HUMAN-PLATELETS | - |
dc.subject | WASP VENOM MASTOPARAN | - |
dc.subject | INOSITOL 1,4,5-TRISPHOSPHATE | - |
dc.subject | CONDUCTANCE CHANNEL | - |
dc.subject | GUANYLATE-CYCLASE | - |
dc.subject | HL-60 MEMBRANES | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.title | Induction of cytosolic Ca2+ elevation mediated by Mas-7 occurs through membrane pore formation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1074/jbc.271.51.32753 | - |
dc.author.google | Suh, BC | - |
dc.author.google | Song, SK | - |
dc.author.google | Kim, YK | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 271 | - |
dc.relation.issue | 51 | - |
dc.relation.startpage | 32753 | - |
dc.relation.lastpage | 32759 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.271, no.51, pp.32753 - 32759 | - |
dc.identifier.wosid | A1996VZ37300045 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 32759 | - |
dc.citation.number | 51 | - |
dc.citation.startPage | 32753 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 271 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-0030299825 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 42 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NUCLEOSIDE DIPHOSPHATE KINASE | - |
dc.subject.keywordPlus | GTP-BINDING PROTEINS | - |
dc.subject.keywordPlus | NEUROBLASTOMA SK-N-BE(2)C CELLS | - |
dc.subject.keywordPlus | FURA-2-LOADED HUMAN-PLATELETS | - |
dc.subject.keywordPlus | WASP VENOM MASTOPARAN | - |
dc.subject.keywordPlus | INOSITOL 1,4,5-TRISPHOSPHATE | - |
dc.subject.keywordPlus | CONDUCTANCE CHANNEL | - |
dc.subject.keywordPlus | GUANYLATE-CYCLASE | - |
dc.subject.keywordPlus | HL-60 MEMBRANES | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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