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Synthesis of 2-isoxazoline and alpha-hydroxy ketomethylene dipeptide isosteres SCIE SCOPUS
- Title
- Synthesis of 2-isoxazoline and alpha-hydroxy ketomethylene dipeptide isosteres
- Date Issued
- 1996-02
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- We have developed a simple and stereoselective method for synthesizing novel dipeptide isosteres using nitrile oxide cycloaddition as a key reaction. Employing this method, we have prepared efficiently various peptidomimetics containing 2-isoxazolines and alpha-hydroxy ketomethylene dipeptide isosteres.
- Keywords
- dipeptide isostere; peptidomimetics; nitrile oxide cycloaddition; 2-isoxazoline; alpha-hydroxy ketomethylene; NITRILE OXIDE CYCLOADDITIONS; OPPOLZERS CHIRAL SULTAM; AMINO ALDEHYDES; ASYMMETRIC INDUCTION; ORGANIC-SYNTHESIS; PRACTICAL METHOD; AIDS; PEPTIDE; RENIN; DELTA-2-ISOXAZOLINES
- ISSN
- 0968-0896
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY, vol. 4, no. 2, page. 209 - 225, 1996-02
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Related Researcher
- 김병현KIM, BYEANG HYEAN
- Div of Advanced Materials Science