TRANSCRIPTIONAL REGULATION OF PHOSPHOLIPASE C-GAMMA-1 GENE DURING MUSCLE DIFFERENTIATION
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SCOPUS
- Title
- TRANSCRIPTIONAL REGULATION OF PHOSPHOLIPASE C-GAMMA-1 GENE DURING MUSCLE DIFFERENTIATION
- Authors
- LEE, SJ; LEE, YH; KIM, YS; RYU, SH; SUH, PG
- Date Issued
- 1995-01-05
- Publisher
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPT
- Abstract
- Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-gamma 1 during myogenic differentiation. Both PLC-gamma 1 mRNA and protein levels were increased during myogenesis. The activity of PLC-gamma 1 was also comparable to the amount estimated by Western blot. Comparing promoter activities of various PLC-gamma 1 gene upstream regions in myoblast and myotube, the responsible region was mapped between -551 and -480. From these results, we conclude that the transcription of PLC-gamma 1. is increased by the control of GPE1 region of PLC-gamma 1 gene during myogenesis. (C) 1995 Academic Press, Inc.
- Keywords
- PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PROMOTER REGION; BOVINE BRAIN; C ISOZYMES; PROTEIN; LOCALIZATION; HYDROLYSIS; BINDING; GAMMA
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/21865
- DOI
- 10.1006/bbrc.1995.1027
- ISSN
- 0006-291X
- Article Type
- Article
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 206, no. 1, page. 194 - 200, 1995-01-05
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- There are no files associated with this item.
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