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NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS CONTAINING ALPHA-HYDROXY KETOMETHYLENE DIPEPTIDE ISOSTERES SCIE SCOPUS
- Title
- NOVEL ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS CONTAINING ALPHA-HYDROXY KETOMETHYLENE DIPEPTIDE ISOSTERES
- Date Issued
- 1994-12-08
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Abstract
- Synthesis of novel angiotensin converting enzyme inhibitors has been accomplished using the alpha-hydroxy ketomethylene dipeptide isostere as a key constituent. (2R, 5S)-2-hydroxy-5-benzamido-4-oxo-6-phenyl hexanoyl (S)-(-)-indoline-2-carboxylic acid (7) showed potent inhibitory activity against angiotensin converting enzyme, IC50 = 0.09 mu M.
- ISSN
- 0960-894X
- Article Type
- Article
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 23, page. 2799 - 2804, 1994-12-08
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Related Researcher
- 김병현KIM, BYEANG HYEAN
- Div of Advanced Materials Science