ENANTIOSELECTIVE SYNTHESES OF (+)-METHYL NONACTATE AND (-)-METHYL 8-EPI-NONACTATE VIA ASYMMETRIC CYCLOADDITIVE ROUTE

Abstract

Enantioselective routes to (+)-methyl nonactate (2) and (-)-methyl 8-epi-nonactate (3) are described. The cornerstone of this synthetic strategy is a combination of asymmetric silyl nitronate cycloaddition and asymmetric reduction, which provides the key syn-1.3-diol intermediate 4.