DC Field | Value | Language |
---|---|---|
dc.contributor.author | Miniaci, MC | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Puthanveettil, SV | - |
dc.contributor.author | Si, K | - |
dc.contributor.author | Zhu, HX | - |
dc.contributor.author | K | - |
dc.contributor.author | el, ER | - |
dc.contributor.author | Bailey, CH | - |
dc.date.accessioned | 2016-04-01T01:08:55Z | - |
dc.date.available | 2016-04-01T01:08:55Z | - |
dc.date.created | 2009-08-10 | - |
dc.date.issued | 2008-09-25 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.other | 2008-OAK-0000008197 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22472 | - |
dc.description.abstract | The time course of the requirement for local protein synthesis in the stabilization of learning-related synaptic growth and the persistence of long-term memory was examined using Aplysia bifurcated sensory neuron-motor neuron cultures. We find that, following repeated pulses of serotonin (5-HT), the local perfusion of emetine, an inhibitor of protein synthesis, or a TAT-AS oligonucleotide directed against ApCPEB blocks long-term facilitation (LTF) at either 24 or 48 hr and leads to a selective retraction of newly formed sensory neuron varicosities induced by 5-HT. By contrast, later inhibition of local protein synthesis, at 72 hr after 5-HT, has no effect on either synaptic growth or LTF. These results define a specific stabilization phase for the storage of long-term memory during which newly formed varicosities are labile and require sustained CPEB-dependent local protein synthesis to acquire the more stable properties of mature varicosities required for the persistence of LTF. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | NEURON | - |
dc.subject | SENSORY NEURONS | - |
dc.subject | MEMORY STORAGE | - |
dc.subject | STRUCTURAL-CHANGES | - |
dc.subject | WITHDRAWAL REFLEX | - |
dc.subject | GILL-WITHDRAWAL | - |
dc.subject | IN-VIVO | - |
dc.subject | PLASTICITY | - |
dc.subject | SYNAPSES | - |
dc.subject | SENSITIZATION | - |
dc.subject | TRANSIENT | - |
dc.title | Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-terra facilitation in Aplysia | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.NEURON.2008.07.036 | - |
dc.author.google | Miniaci, MC | - |
dc.author.google | Kim, JH | - |
dc.author.google | Puthanveettil, SV | - |
dc.author.google | Si, K | - |
dc.author.google | Zhu, HX | - |
dc.author.google | Kandel, ER | - |
dc.author.google | Bailey, CH | - |
dc.relation.volume | 59 | - |
dc.relation.issue | 6 | - |
dc.relation.startpage | 1024 | - |
dc.relation.lastpage | 1036 | - |
dc.contributor.id | 10114767 | - |
dc.relation.journal | NEURON | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NEURON, v.59, no.6, pp.1024 - 1036 | - |
dc.identifier.wosid | 000259797700017 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1036 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1024 | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 59 | - |
dc.contributor.affiliatedAuthor | Kim, JH | - |
dc.identifier.scopusid | 2-s2.0-52249104915 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 82 | - |
dc.description.scptc | 85 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SENSORY NEURONS | - |
dc.subject.keywordPlus | MEMORY STORAGE | - |
dc.subject.keywordPlus | STRUCTURAL-CHANGES | - |
dc.subject.keywordPlus | WITHDRAWAL REFLEX | - |
dc.subject.keywordPlus | GILL-WITHDRAWAL | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | SYNAPSES | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | TRANSIENT | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
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