The fabrication of rapid prototype based 3D PCL and PLGA scaffolds using precision deposition system

Abstract

The aim of this study is to fabricate scaffolds from two types of biodegradable materials using a precision deposition system that we developed. The precision deposition system, which is one of rapid prototyping(RP) methods, uses technology that enables the manufacture of three-dimensional microstructures. Fabrication of 3D tissue engineering scaffolds using the precision deposition system required the combination of several technologies, including motion control, thermal control. pneumatic control, computer-aided design and computer-aided manufacturing(CAD/CAM) software. Through the fabrication and human bone marrow mesenchymal stem cells(hBMSCs) proliferation experiments of two kinds Of scaffolds using poly(epsilon-caprolactone)(PCL) and poly(lactic-co-glycolic acid)(PLGA), feasibility of application to the tissue engineering of precision deposition system is demonstrated.