DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, JH | - |
dc.contributor.author | Cho, ML | - |
dc.contributor.author | Moon, YM | - |
dc.contributor.author | Oh, HJ | - |
dc.contributor.author | Park, JS | - |
dc.contributor.author | Jhun, JY | - |
dc.contributor.author | Min, SY | - |
dc.contributor.author | Cho, YG | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Yoon, CH | - |
dc.contributor.author | Min, JK | - |
dc.contributor.author | Park, SH | - |
dc.contributor.author | Sung, YC | - |
dc.contributor.author | Kim, HY | - |
dc.date.accessioned | 2016-04-01T01:15:16Z | - |
dc.date.available | 2016-04-01T01:15:16Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2008-07-15 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2008-OAK-0000007976 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22616 | - |
dc.description.abstract | IL-23, a clinically novel cytokine, targets CD4(+) T cells. Recent IL-1Ra(-/-) mouse studies have demonstrated that IL-23 indirectly stimulates the differentiation of osteoclast precursors by enhancing IL-17 release from CD4(+) T cells. IL-17, in turn, stimulates osteoclastogenesis in osteoclast precursor cells. In this study, we found that IL-23 up-regulates receptor activator of NF-kappa B ligand expression by CD4(+) T cells, and thus contributes to osteoclastogenesis. This indirect pathway is mediated by NF-kappa B and STAT3. We have also demonstrated that IL-23 can influence osteoclastogenesis positively under the special conditions in the IL-1-dominant milieu of IL-1Ra(-/-) mice. We propose that IL-23-enhanced osteoclastogenesis is mediated mainly by CD4(+) T cells. The results of this study show that IL-23 is a promising therapeutic target for the treatment of arthritis-associated bone destruction. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | BONE DESTRUCTION | - |
dc.subject | FACTOR-ALPHA | - |
dc.subject | RANKL | - |
dc.subject | EROSION | - |
dc.subject | INTERLEUKIN-17 | - |
dc.subject | STIMULATION | - |
dc.subject | INVOLVEMENT | - |
dc.subject | INDUCTION | - |
dc.title | IL-23 induces receptor activator of NF-kappa B ligand expression on CD4(+) T cells and promotes osteoclastogenesis in an autoimmune arthritis model | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.181.2.1507 | - |
dc.author.google | Ju, JH | - |
dc.author.google | Cho, ML | - |
dc.author.google | Moon, YM | - |
dc.author.google | Oh, HJ | - |
dc.author.google | Park, JS | - |
dc.author.google | Jhun, JY | - |
dc.author.google | Min, SY | - |
dc.author.google | Cho, YG | - |
dc.author.google | Park, KS | - |
dc.author.google | Yoon, CH | - |
dc.author.google | Min, JK | - |
dc.author.google | Park, SH | - |
dc.author.google | Sung, YC | - |
dc.author.google | Kim, HY | - |
dc.relation.volume | 181 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 1507 | - |
dc.relation.lastpage | 1518 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.181, no.2, pp.1507 - 1518 | - |
dc.identifier.wosid | 000257958800073 | - |
dc.date.tcdate | 2018-12-01 | - |
dc.citation.endPage | 1518 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1507 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 181 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-49049103008 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 65 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | BONE DESTRUCTION | - |
dc.subject.keywordPlus | FACTOR-ALPHA | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordPlus | EROSION | - |
dc.subject.keywordPlus | INTERLEUKIN-17 | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.