DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, DJ | - |
dc.contributor.author | Youn, JI | - |
dc.contributor.author | Seo, SH | - |
dc.contributor.author | Jin, HT | - |
dc.contributor.author | Sung, YC | - |
dc.date.accessioned | 2016-04-01T01:17:00Z | - |
dc.date.available | 2016-04-01T01:17:00Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2008-06-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.other | 2008-OAK-0000007929 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22656 | - |
dc.description.abstract | IL-12p40 is a natural antagonist which inhibits IL-12- and IL-23-mediated biological activity by blocking the binding of IL-12/23 to their receptors. Recently, IL-12p40 was also shown to have immune-enhancing activity through the activation of macrophages or dendritic cells. In this study, we investigated the effects of IL-12p40 as a genetic adjuvant on immune modulation using recombinant adenoviruses expressing IL-12p40 (rAd/IL-12p40) and OVA (rAd/OVA). Coimmunization of rAd/IL-12p40 at a low dose (1 x 10(4) PFU) with rAd/OVA resulted in OVA-specific immune enhancement, while a high dose of rAd/IL-12p40 (1 x 10(8) PFU) caused significant suppression of CD8(+) T cell responses. In addition, the enhancement and suppression of OVA-specific CD8(+) T cell responses correlated with antitumor activity against E.G7-OVA tumor challenge, which subsequently affected the survival rate. Moreover, the differential CD8(+) T cell response by IL-12p40 was still observed in IL-12R beta 2 knockout (IL-12R beta 2KO), but not in IL-12R beta 1 knockout (IL-12R beta 1KO) mice, indicating that IL-12p40 is a cytokine which can modulate Ag-specific T cell responses depending on IL-12R beta 1. Our findings provide a novel insight on the physiological role of IL-12p40, which can be informative in the design of vaccine strategies and therapeutic regimens. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | NATURAL-KILLER-CELLS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | P40 HOMODIMER | - |
dc.subject | STIMULATORY FACTOR | - |
dc.subject | TYROSINE PHOSPHORYLATION | - |
dc.subject | HETERODIMERIC CYTOKINE | - |
dc.subject | INTERLEUKIN-12 P40 | - |
dc.subject | SIGNAL TRANSDUCER | - |
dc.subject | HUMAN-LYMPHOCYTES | - |
dc.title | Differential regulation of antigen-specific CD8(+) T cell responses by IL-12p40 in a dose-dependent manner | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.4049/jimmunol.180.11.7167 | - |
dc.author.google | Kim, DJ | - |
dc.author.google | Youn, JI | - |
dc.author.google | Seo, SH | - |
dc.author.google | Jin, HT | - |
dc.author.google | Sung, YC | - |
dc.relation.volume | 180 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 7167 | - |
dc.relation.lastpage | 7174 | - |
dc.contributor.id | 10053752 | - |
dc.relation.journal | JOURNAL OF IMMUNOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.180, no.11, pp.7167 - 7174 | - |
dc.identifier.wosid | 000257507300012 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 7174 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 7167 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 180 | - |
dc.contributor.affiliatedAuthor | Sung, YC | - |
dc.identifier.scopusid | 2-s2.0-47249130756 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NATURAL-KILLER-CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | P40 HOMODIMER | - |
dc.subject.keywordPlus | STIMULATORY FACTOR | - |
dc.subject.keywordPlus | TYROSINE PHOSPHORYLATION | - |
dc.subject.keywordPlus | HETERODIMERIC CYTOKINE | - |
dc.subject.keywordPlus | INTERLEUKIN-12 P40 | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCER | - |
dc.subject.keywordPlus | HUMAN-LYMPHOCYTES | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
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