DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, S | - |
dc.contributor.author | Choi, JW | - |
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Kim, YH | - |
dc.contributor.author | Yea, K | - |
dc.contributor.author | Heo, K | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Song, M | - |
dc.contributor.author | Il Kim, J | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-04-01T01:23:42Z | - |
dc.date.available | 2016-04-01T01:23:42Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2008-03-26 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.other | 2008-OAK-0000007648 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22832 | - |
dc.description.abstract | Mast cells play a central role in allergic disease and host defense against several pathogens through the release of various bioactive compounds via degranulation. In this study, we found that a myristoylated pseudosubstrate of PKC-zeta (zeta-PS; myristoyl-SIYRRGARRWRKL, a PKC-zeta inhibitor) regulates mast cell degranulation. zeta-PS increased [Ca+2](i) level at nanomolar concentrations in a PKC-zeta activity-independent manner in HMC-1 cells. Moreover, zeta-PS-induced [Ca+2](i) generation was completely abrogated by phospholipase C (PLC), IP3 receptor or G alpha(i/o). inhibitor and zeta-PS potently induced degranulation in HMC-1 cells which was significantly inhibited by pretreating PLC inhibitors or a calcium chelator. Therefore, our results suggest that zeta-PS can induce degranulation in HMC-1 cells by triggering the calcium signal via a PKC-zeta-independent but G alpha(i/o), PLC and IP3-dependent pathways. (c) 2008 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | LIFE SCIENCES | - |
dc.subject | zeta-PS | - |
dc.subject | mast cells | - |
dc.subject | calcium | - |
dc.subject | phospholipase C | - |
dc.subject | IP3 | - |
dc.subject | degranulation | - |
dc.subject | PERITONEAL MAST-CELLS | - |
dc.subject | HISTAMINE-RELEASE | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | ACTIVATION | - |
dc.subject | CALCIUM | - |
dc.subject | GENERATION | - |
dc.subject | INHIBITOR | - |
dc.subject | RECEPTORS | - |
dc.subject | MECHANISM | - |
dc.subject | EFFECTOR | - |
dc.title | A myristoylated pseudosubstrate peptide of PKC-zeta induces degranulation in HMC-1 cells independently of PKC-zeta activity | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.LFS.2008.01.005 | - |
dc.author.google | Lim, S | - |
dc.author.google | Choi, JW | - |
dc.author.google | Kim, HS | - |
dc.author.google | Kim, YH | - |
dc.author.google | Yea, K | - |
dc.author.google | Heo, K | - |
dc.author.google | Kim, JH | - |
dc.author.google | Kim, SH | - |
dc.author.google | Song, M | - |
dc.author.google | Il Kim, J | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 82 | - |
dc.relation.issue | 13-14 | - |
dc.relation.startpage | 733 | - |
dc.relation.lastpage | 740 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | LIFE SCIENCES | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | LIFE SCIENCES, v.82, no.13-14, pp.733 - 740 | - |
dc.identifier.wosid | 000254691700008 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 740 | - |
dc.citation.number | 13-14 | - |
dc.citation.startPage | 733 | - |
dc.citation.title | LIFE SCIENCES | - |
dc.citation.volume | 82 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-40849094196 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 15 | - |
dc.description.scptc | 15 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PERITONEAL MAST-CELLS | - |
dc.subject.keywordPlus | HISTAMINE-RELEASE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordAuthor | zeta-PS | - |
dc.subject.keywordAuthor | mast cells | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | phospholipase C | - |
dc.subject.keywordAuthor | IP3 | - |
dc.subject.keywordAuthor | degranulation | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
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