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TWO-PHOTON FLUORESCENT TURN-ON PROBE FOR LIPID RAFTS IN LIVE CELL AND TISSUE SCIE SCOPUS
- Title
- TWO-PHOTON FLUORESCENT TURN-ON PROBE FOR LIPID RAFTS IN LIVE CELL AND TISSUE
- Authors
- Kim, HM; Jeong, BH; Hyon, JY; An, MJ; Seo, MS; Hong, JH; Lee, KJ; Kim, CH; Joo, TH; Hong, SC; Cho, BR
- Date Issued
- 2008-04-02
- Publisher
- AMER CHEMICAL SOC
- Abstract
- We report a new two-photon fluorescence turn-on probe 6-[(E)-3-oxo-1-dodecenyl]-2-[N-methyl-N-(carboxymethyl)amino]naphthalene (CL2) that is designed specifically for visualizing lipid rafts in living cells and tissues. This probe emits much brighter two-photon excited fluorescence in lipid rafts than in non-raft domains and allows direct visualization of the lipid rafts in the live cells and pyramidal neuron layer of the CA1 region at a depth of 100-250 mu m in live tissues using two-photon microscopy.
- Keywords
- DOMAINS; MICROSCOPY; CAVEOLAE
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 130, no. 13, page. 4246 - 4247, 2008-04-02
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Related Researcher
- 주태하JOO, TAIHA
- Dept of Chemistry