DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, S | - |
dc.contributor.author | Jeon, J | - |
dc.contributor.author | Yang, S | - |
dc.contributor.author | Kim, S | - |
dc.date.accessioned | 2016-04-01T01:24:37Z | - |
dc.date.available | 2016-04-01T01:24:37Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.issn | 0887-3585 | - |
dc.identifier.other | 2008-OAK-0000007600 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22866 | - |
dc.description.abstract | Symmetry plays significant roles in protein structure and function. Particularly, symmetric interfaces are known to act as switches for two-state conformational change. Membrane proteins often undergo two-state conformational change during the transport process of ion channels or the active/inactive transitions in receptors. Here, we provide the first comprehensive analyses of internal repeat symmetry in membrane proteins. We examined the known membrane protein structures and found that, remarkably, nearly half of them have internal repeat symmetry. Moreover, we found that the conserved cores of these internal repeats are positioned at the interface of symmetric units when they are mapped on structures. Because Of the large sequence divergence that occurs between internal repeats, the inherent symmetry present in protein sequences often has only been detected after structure determination. We therefore developed a sensitive procedure to predict the internal repeat symmetry from sequence information and identified 4653 proteins that are likely to have internal repeat symmetry. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | WILEY-LISS | - |
dc.relation.isPartOf | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | - |
dc.subject | protein structure | - |
dc.subject | sequence analysis | - |
dc.subject | transmembrane proteins | - |
dc.subject | ion channels | - |
dc.subject | structural bioinformatics | - |
dc.subject | MITOCHONDRIAL ADP/ATP CARRIER | - |
dc.subject | COMBINATORIAL EXTENSION CE | - |
dc.subject | X-RAY-STRUCTURE | - |
dc.subject | TRANSMEMBRANE PROTEINS | - |
dc.subject | SECONDARY STRUCTURE | - |
dc.subject | ENERGY LANDSCAPES | - |
dc.subject | CHLORIDE CHANNEL | - |
dc.subject | ION-CHANNEL | - |
dc.subject | SEQUENCE | - |
dc.subject | EVOLUTION | - |
dc.title | Common occurrence of internal repeat symmetry in membrane proteins | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1002/PROT.21656 | - |
dc.author.google | Choi, S | - |
dc.author.google | Jeon, J | - |
dc.author.google | Yang, S | - |
dc.author.google | Kim, S | - |
dc.relation.volume | 71 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 68 | - |
dc.relation.lastpage | 80 | - |
dc.contributor.id | 10136479 | - |
dc.relation.journal | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, v.71, no.1, pp.68 - 80 | - |
dc.identifier.wosid | 000254035500008 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 80 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.title | PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | - |
dc.citation.volume | 71 | - |
dc.contributor.affiliatedAuthor | Kim, S | - |
dc.identifier.scopusid | 2-s2.0-40549125974 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.description.scptc | 18 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MITOCHONDRIAL ADP/ATP CARRIER | - |
dc.subject.keywordPlus | COMBINATORIAL EXTENSION CE | - |
dc.subject.keywordPlus | X-RAY-STRUCTURE | - |
dc.subject.keywordPlus | TRANSMEMBRANE PROTEINS | - |
dc.subject.keywordPlus | SECONDARY STRUCTURE | - |
dc.subject.keywordPlus | ENERGY LANDSCAPES | - |
dc.subject.keywordPlus | CHLORIDE CHANNEL | - |
dc.subject.keywordPlus | ION-CHANNEL | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | EVOLUTION | - |
dc.subject.keywordAuthor | protein structure | - |
dc.subject.keywordAuthor | sequence analysis | - |
dc.subject.keywordAuthor | transmembrane proteins | - |
dc.subject.keywordAuthor | ion channels | - |
dc.subject.keywordAuthor | structural bioinformatics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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