DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, TH | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-04-01T01:26:37Z | - |
dc.date.available | 2016-04-01T01:26:37Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2008-01 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.other | 2008-OAK-0000007496 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/22941 | - |
dc.description.abstract | Vaccinia-related kinase 3 (VRK3), previously characterized as a direct activator of vaccinia HI-related (VHR) phosphatase, inactivates extracellular signal-regulated kinase (ERK) in the nucleus of neuronal cells. Here we show that VRK3 is expressed in various other rodent tissues and in embryos, and regulates VHR phosphatase activity in these tissues. We observed colocalization of VRK3 and VHR in the testis tissue and could detect protein complex containing VRK3, VHR and ERK in immunoprecipitation analysis. Notably, the addition of recombinant VRK3 protein to total protein lysates, obtained either from adult tissues or embryos, enhanced the phosphatase activity of VHR, but not the activity of MKP3. The results further indicate that the VHR-VRK3 complex is a phosphatase-active form. In addition, we found that VRK3 can regulate EGF-induced cellular growth signaling that is mediated by ERK activation. Our results suggest that in addition to neuronal cells, various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated VHR activity. (C) 2007 Elsevier B.V. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.subject | vaccinia-related kinase 3 | - |
dc.subject | vaccinia H1-related phosphatase | - |
dc.subject | extracellular signal-regulated kinase | - |
dc.subject | mitogen-activated protein kinase phosphatase | - |
dc.subject | VACCINIA-RELATED KINASE-1 | - |
dc.subject | MAP KINASE | - |
dc.subject | REGULATED KINASES | - |
dc.subject | LEYDIG-CELLS | - |
dc.subject | PHOSPHATASE-1 DEGRADATION | - |
dc.subject | VHR PHOSPHATASE | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEIN | - |
dc.subject | SPECIFICITY | - |
dc.title | VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.BBAMCR.2007.10.011 | - |
dc.author.google | Kang, TH | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 1783 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 49 | - |
dc.relation.lastpage | 58 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1783, no.1, pp.49 - 58 | - |
dc.identifier.wosid | 000253016100005 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.citation.volume | 1783 | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-38049016957 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 13 | - |
dc.description.scptc | 13 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REGULATED KINASES | - |
dc.subject.keywordPlus | LEYDIG-CELLS | - |
dc.subject.keywordPlus | PHOSPHATASE-1 DEGRADATION | - |
dc.subject.keywordPlus | VHR PHOSPHATASE | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | VACCINIA-RELATED KINASE-1 | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordAuthor | vaccinia-related kinase 3 | - |
dc.subject.keywordAuthor | vaccinia H1-related phosphatase | - |
dc.subject.keywordAuthor | extracellular signal-regulated kinase | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase phosphatase | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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