DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, WJ | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Jang, SK | - |
dc.date.accessioned | 2016-04-01T01:29:20Z | - |
dc.date.available | 2016-04-01T01:29:20Z | - |
dc.date.created | 2009-08-19 | - |
dc.date.issued | 2007-12-12 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.other | 2008-OAK-0000007354 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23042 | - |
dc.description.abstract | The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ2 to eIF4A blocks the interaction between eIF4A and eIF4G that is essential for translation of many mRNAs. Cysteine 264 in eIF4A is the target site of 15d-PGJ2. The antineoplastic activity of 15d-PGJ2 is likely attributed to inhibition of translation. Moreover, inhibition of translation by 15d-PGJ2 results in stress granule (SG) formation, into which TRAF2 is sequestered. The sequestration of TRAF2 contributes to the anti-inflammatory activity of 15d-PGJ2. These findings reveal a novel crosstalk between translation and inflammatory response, and offer new approaches to develop anticancer and anti-inflammatory drugs that target translation factors including eIF4A. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | EMBO JOURNAL | - |
dc.subject | eIF4A | - |
dc.subject | 15d-PGJ2 | - |
dc.subject | inflammation | - |
dc.subject | proliferation | - |
dc.subject | translation | - |
dc.subject | TRANSFORMATION SUPPRESSOR PDCD4 | - |
dc.subject | STRESS GRANULE FORMATION | - |
dc.subject | PRODUCT PATEAMINE-A | - |
dc.subject | KAPPA-B ACTIVATION | - |
dc.subject | RNA HELICASE EIF4A | - |
dc.subject | HEPATITIS-C VIRUS | - |
dc.subject | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) | - |
dc.subject | INITIATION CODON | - |
dc.subject | BINDING-PROTEIN | - |
dc.subject | PATHWAY | - |
dc.title | Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/sj.emboj.7601920 | - |
dc.author.google | Kim, WJ | - |
dc.author.google | Kim, JH | - |
dc.author.google | Jang, SK | - |
dc.relation.volume | 26 | - |
dc.relation.issue | 24 | - |
dc.relation.startpage | 5020 | - |
dc.relation.lastpage | 5032 | - |
dc.contributor.id | 10088382 | - |
dc.relation.journal | EMBO JOURNAL | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EMBO JOURNAL, v.26, no.24, pp.5020 - 5032 | - |
dc.identifier.wosid | 000251613900009 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 5032 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | 5020 | - |
dc.citation.title | EMBO JOURNAL | - |
dc.citation.volume | 26 | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.identifier.scopusid | 2-s2.0-37149023303 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 60 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TRANSFORMATION SUPPRESSOR PDCD4 | - |
dc.subject.keywordPlus | STRESS GRANULE FORMATION | - |
dc.subject.keywordPlus | PRODUCT PATEAMINE-A | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | RNA HELICASE EIF4A | - |
dc.subject.keywordPlus | HEPATITIS-C VIRUS | - |
dc.subject.keywordPlus | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) | - |
dc.subject.keywordPlus | INITIATION CODON | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | eIF4A | - |
dc.subject.keywordAuthor | 15d-PGJ2 | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | proliferation | - |
dc.subject.keywordAuthor | translation | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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