DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Yumkham, S | - |
dc.contributor.author | Choi, JH | - |
dc.contributor.author | Kim, EK | - |
dc.contributor.author | Kim, YS | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-04-01T01:50:59Z | - |
dc.date.available | 2016-04-01T01:50:59Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2006-08-31 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | 2006-OAK-0000006201 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23841 | - |
dc.description.abstract | Haloperidol is a classical neuroleptic drug that is still in clinical use and can lead to abnormal motor activity following repeated administration. However, there is little knowledge of how it triggers neuronal impairment. In this study, we report that it induced calcium ion influx via L-type calcium channels and that the elevation of calcium ions induced by haloperidol appeared to render hippocampal cells more susceptible to oxidative stress. Indeed, the level of cytotoxic reactive oxygen species (ROS) and the expression of proapoptotic Bax increased in response to oxidative stress in haloperidol-treated cells, and these effects were inhibited by verapamil, a specific L-type calcium channel blocker, but not by the T-type calcium channel blocker, mibefradil. These findings indicate that haloperidol induces calcium ion influx via L-type calcium channels and that this calcium influx influences neuronal fate. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | SPRINGER SINGAPORE PTE LTD | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.subject | calcium | - |
dc.subject | haloperidol | - |
dc.subject | hippocampus | - |
dc.subject | L-type calcium channel | - |
dc.subject | oxidative stress | - |
dc.subject | verapamil | - |
dc.subject | INTRACELLULAR CALCIUM | - |
dc.subject | RECEPTOR | - |
dc.subject | DEATH | - |
dc.subject | MECHANISMS | - |
dc.subject | NEUROLEPTICS | - |
dc.subject | SYMPTOMS | - |
dc.title | Haloperidol induces calcium ion influx via L-type calcium channels in hippocampal HN33 cells and renders the neurons more susceptible to oxidative stress | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.author.google | Kim, HS | - |
dc.author.google | Yumkham, S | - |
dc.author.google | Choi, JH | - |
dc.author.google | Kim, EK | - |
dc.author.google | Kim, YS | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 22 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 51 | - |
dc.relation.lastpage | 57 | - |
dc.contributor.id | 10052640 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.22, no.1, pp.51 - 57 | - |
dc.identifier.wosid | 000240323200008 | - |
dc.date.tcdate | 2018-11-01 | - |
dc.citation.endPage | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 51 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 22 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 5 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INTRACELLULAR CALCIUM | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEUROLEPTICS | - |
dc.subject.keywordPlus | SYMPTOMS | - |
dc.subject.keywordAuthor | calcium | - |
dc.subject.keywordAuthor | haloperidol | - |
dc.subject.keywordAuthor | hippocampus | - |
dc.subject.keywordAuthor | L-type calcium channel | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | verapamil | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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