DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Y | - |
dc.contributor.author | Sung, JY | - |
dc.contributor.author | Ceglia, I | - |
dc.contributor.author | Lee, KW | - |
dc.contributor.author | Ahn, JH | - |
dc.contributor.author | Halford, JM | - |
dc.contributor.author | Kim, AM | - |
dc.contributor.author | Kwak, SP | - |
dc.contributor.author | Park, JB | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Schenck, A | - |
dc.contributor.author | Bardoni, B | - |
dc.contributor.author | Scott, JD | - |
dc.contributor.author | Nairn, AC | - |
dc.contributor.author | Greengard, P | - |
dc.date.accessioned | 2016-04-01T01:51:41Z | - |
dc.date.available | 2016-04-01T01:51:41Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2006-08-17 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.other | 2006-OAK-0000006156 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23867 | - |
dc.description.abstract | WAVE1 - the Wiskott - Aldrich syndrome protein ( WASP)- family verprolin homologous protein 1 - is a key regulator of actin-dependent morphological processes(1) in mammals, through its ability to activate the actin-related protein (Arp2/3) complex. Here we show that WAVE1 is phosphorylated at multiple sites by cyclin-dependent kinase 5 (Cdk5) both in vitro and in intact mouse neurons. Phosphorylation of WAVE1 by Cdk5 inhibits its ability to regulate Arp2/3 complex-dependent actin polymerization. Loss of WAVE1 function in vivo or in cultured neurons results in a decrease in mature dendritic spines. Expression of a dephosphorylation-mimic mutant of WAVE1 reverses this loss of WAVE1 function in spine morphology, but expression of a phosphorylation-mimic mutant does not. Cyclic AMP ( cAMP) signalling reduces phosphorylation of the Cdk5 sites in WAVE1, and increases spine density in a WAVE1-dependent manner. Our data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.relation.isPartOf | NATURE | - |
dc.subject | CYCLIN-DEPENDENT KINASE-5 | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | FAMILY PROTEINS | - |
dc.subject | ARP2/3 COMPLEX | - |
dc.subject | SMALL GTPASES | - |
dc.subject | CDK5 | - |
dc.subject | WASP | - |
dc.subject | DOPAMINE | - |
dc.subject | NEURONS | - |
dc.subject | COCAINE | - |
dc.title | Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/NATURE04976 | - |
dc.author.google | Kim, Y | - |
dc.author.google | Sung, JY | - |
dc.author.google | Ceglia, I | - |
dc.author.google | Lee, KW | - |
dc.author.google | Ahn, JH | - |
dc.author.google | Halford, JM | - |
dc.author.google | Kim, AM | - |
dc.author.google | Kwak, SP | - |
dc.author.google | Park, JB | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Schenck, A | - |
dc.author.google | Bardoni, B | - |
dc.author.google | Scott, JD | - |
dc.author.google | Nairn, AC | - |
dc.author.google | Greengard, P | - |
dc.relation.volume | 442 | - |
dc.relation.issue | 7104 | - |
dc.relation.startpage | 814 | - |
dc.relation.lastpage | 817 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | NATURE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE, v.442, no.7104, pp.814 - 817 | - |
dc.identifier.wosid | 000239792700046 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 817 | - |
dc.citation.number | 7104 | - |
dc.citation.startPage | 814 | - |
dc.citation.title | NATURE | - |
dc.citation.volume | 442 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-33747482904 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 196 | - |
dc.description.scptc | 200 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CYCLIN-DEPENDENT KINASE-5 | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | FAMILY PROTEINS | - |
dc.subject.keywordPlus | ARP2/3 COMPLEX | - |
dc.subject.keywordPlus | SMALL GTPASES | - |
dc.subject.keywordPlus | CDK5 | - |
dc.subject.keywordPlus | WASP | - |
dc.subject.keywordPlus | DOPAMINE | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | COCAINE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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