DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JI | - |
dc.contributor.author | Lee, HY | - |
dc.contributor.author | Park, KS | - |
dc.contributor.author | Lee, T | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Bae, YS | - |
dc.date.accessioned | 2016-04-01T01:52:00Z | - |
dc.date.available | 2016-04-01T01:52:00Z | - |
dc.date.created | 2009-08-13 | - |
dc.date.issued | 2006-09-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2006-OAK-0000006141 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/23879 | - |
dc.description.abstract | Lipopolysaccharide (LPS) is critically involved in the inflammatory responses via generation of several pro-inflammatory cytokines. Since tumor necrosis factor-alpha (TNF-alpha) is one of the major pro-inflammatory cytokines which is induced by LPS treatment, the development of molecules capable of modulating LPS-induced TNF-alpha production is an issue of concern. We identified a novel synthetic compound that inhibits LPS-induced TNF-alpha production in human peripheral blood mononuclear cells (PBMCs). The active compound SM-7409 inhibited LPS-induced TNF-alpha production in a concentration-dependent manner, showing maximal activity at 5 mu M. SM-7409 inhibited LPS-induced TNF-alpha mRNA transcript accumulation and protein expression. We also found that SM-7409 strongly inhibits LPS-induced extracellular signal-regulated protein kinase activity in PBMCs. Moreover, we found that SM-7409 strongly inhibits the LPS-induced other pro-inflammatory cytokines, such as interleukin (IL)-1 beta and IL-8 in PBMCs. SM-7409 also dramatically inhibits the LPS-induced TNF-alpha production in neutrophils. Taken together, our results demonstrate that SM-7409 is a synthetic compound that inhibits LPS-induced TNF-alpha production, and thus SM-7409 should be useful for the development of chemotherapies targeting LPS-mediated inflammatory responses. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | lipopolysaccharide | - |
dc.subject | TNF-alpha | - |
dc.subject | small compound | - |
dc.subject | peripheral blood mononuclear cells | - |
dc.subject | ERK | - |
dc.subject | TOLL-LIKE RECEPTORS | - |
dc.subject | INFLAMMATORY RESPONSES | - |
dc.subject | ORGAN FAILURE | - |
dc.subject | GRAIN DUST | - |
dc.subject | CELL | - |
dc.subject | IDENTIFICATION | - |
dc.subject | ENDOTOXIN | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | INHALATION | - |
dc.subject | PATHWAY | - |
dc.title | A small compound that inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.06.155 | - |
dc.author.google | Kim, JI | - |
dc.author.google | Lee, HY | - |
dc.author.google | Park, KS | - |
dc.author.google | Lee, T | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Bae, YS | - |
dc.relation.volume | 347 | - |
dc.relation.issue | 3 | - |
dc.relation.startpage | 797 | - |
dc.relation.lastpage | 802 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.347, no.3, pp.797 - 802 | - |
dc.identifier.wosid | 000239587200036 | - |
dc.date.tcdate | 2018-11-01 | - |
dc.citation.endPage | 802 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 797 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 347 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-33746214639 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 1 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSES | - |
dc.subject.keywordPlus | ORGAN FAILURE | - |
dc.subject.keywordPlus | GRAIN DUST | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | ENDOTOXIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | INHALATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | TNF-alpha | - |
dc.subject.keywordAuthor | small compound | - |
dc.subject.keywordAuthor | peripheral blood mononuclear cells | - |
dc.subject.keywordAuthor | ERK | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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