Internal initiation: IRES elements of picornaviruses and hepatitis c virus
SCIE
SCOPUS
- Title
- Internal initiation: IRES elements of picornaviruses and hepatitis c virus
- Authors
- Jang, SK
- Date Issued
- 2006-07
- Publisher
- ELSEVIER SCIENCE BV
- Abstract
- The scanning hypothesis provides an explanation for events preceding the first peptide bond formation during the translation of the vast majority of eukaryotic mRNAs. However, this hypothesis does not explain the translation of eukaryotic mRNAs lacking the cap structure required for scanning. The existence of a group of positive sense RNA viruses lacking cap structures (e.g. picomaviruses) indicates that host cells also contain a 5' cap-independent translation mechanism. This review discusses the translation mechanisms of atypical viral mRNAs such as picornaviruses and hepatitis c virus, and uses these mechanisms to propose a general theme for all translation, including that of both eukaryotic and prokaryotic mRNAs. (c) 2005 Elsevier B.V. All rights reserved.
- Keywords
- picornaviruses; Hepatitis c virus (HCV); translation; internal ribosomal entry site (IRES); regulation of translation; RIBOSOME ENTRY SITE; TRACT-BINDING-PROTEIN; CAP-INDEPENDENT TRANSLATION; EUKARYOTIC MESSENGER-RNA; MOUTH-DISEASE VIRUS; HUMAN RHINOVIRUS RNA; INTERGENERIC POLIOVIRUS RECOMBINANTS; 5' NONTRANSLATED REGION; COLD-SHOCK DOMAINS; FACTOR 4G EIF4G
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/23979
- DOI
- 10.1016/j.virusres.2005.11.003
- ISSN
- 0168-1702
- Article Type
- Article
- Citation
- VIRUS RESEARCH, vol. 119, no. 1, page. 2 - 15, 2006-07
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- There are no files associated with this item.
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