DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, HS | - |
dc.contributor.author | Yumkham, S | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Yea, K | - |
dc.contributor.author | Shin, YC | - |
dc.contributor.author | Ryu, SH | - |
dc.contributor.author | Suh, PG | - |
dc.date.accessioned | 2016-04-01T01:59:09Z | - |
dc.date.available | 2016-04-01T01:59:09Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2006-02-28 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.other | 2006-OAK-0000005757 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24152 | - |
dc.description.abstract | The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area, we have attempted to determine the effects of secretin on neuronal differentiation. Here, we report that secretin induces the generation of neurite outgrowth in pheochromocytoma PC12 cells. The expressions of Tau and beta-tubulin, neuronal differentiation markers, are increased upon secretin stimulation. In addition, secretin induces sustained mitogen-activated protein kinase (MAPK) activation and also stimulates the cAMP secretion. Moreover, the neurite outgrowth elicited by secretin is suppressed to a marked degree in the presence of either PD98059, a specific MAPK/ERK kinase (MEK) inhibitor, or H89, a specific protein kinase A (PKA) inhibitor. Taken together, these observations demonstrate that secretin induces neurite outgrowth of PC12 cells through cAMP-MAPK pathway, and provide a novel insight into the manner in which secretin participates in neuritogenesis. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MED BIOCHEMISTRY MOLECULAR | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.title | Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1038/emm.2006.10 | - |
dc.author.google | Kim, HS | - |
dc.author.google | Yumkham, S | - |
dc.author.google | Kim, SH | - |
dc.author.google | Yea, K | - |
dc.author.google | Shin, YC | - |
dc.author.google | Ryu, SH | - |
dc.author.google | Suh, PG | - |
dc.relation.volume | 38 | - |
dc.relation.issue | 1 | - |
dc.relation.startpage | 85 | - |
dc.relation.lastpage | 93 | - |
dc.contributor.id | 10069853 | - |
dc.relation.journal | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.38, no.1, pp.85 - 93 | - |
dc.identifier.wosid | 000235877100010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 93 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 85 | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 38 | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.contributor.affiliatedAuthor | Suh, PG | - |
dc.identifier.scopusid | 2-s2.0-33644808833 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 20 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | VASOACTIVE-INTESTINAL-PEPTIDE | - |
dc.subject.keywordPlus | MAP KINASE | - |
dc.subject.keywordPlus | CYCLIC-AMP | - |
dc.subject.keywordPlus | NEURONAL DIFFERENTIATION | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | TAU | - |
dc.subject.keywordAuthor | mitogen-activated protein kinases | - |
dc.subject.keywordAuthor | neurites | - |
dc.subject.keywordAuthor | pheochromocytoma | - |
dc.subject.keywordAuthor | secretin | - |
dc.subject.keywordAuthor | tau proteins | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.