DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, TD | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Myung, J | - |
dc.contributor.author | Chae, HD | - |
dc.contributor.author | Woo, KC | - |
dc.contributor.author | Jang, SK | - |
dc.contributor.author | Koh, DS | - |
dc.contributor.author | Kim, KT | - |
dc.date.accessioned | 2016-04-01T02:12:52Z | - |
dc.date.available | 2016-04-01T02:12:52Z | - |
dc.date.created | 2009-02-28 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.issn | 0270-7306 | - |
dc.identifier.other | 2005-OAK-0000005008 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/24671 | - |
dc.description.abstract | Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) is the key enzyme in melatonin synthesis regulated by circadian rhythm. To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations of AANAT mRNA. In this study, we identify three proteins from pineal glands that associate with cis-acting elements within species-specific AANAT 3' untranslated regions to mediate mRNA degradation. These proteins include heterogeneous nuclear ribonucleoprotein R (hnRNP R), hnRNP` Q, and hnRNP L. Their RNA-destabilizing function was determined by RNA interference and overexpression approaches. Expression patterns of these factors in pineal glands display robust circadian rhythm. The enhanced levels detected after midnight correlate with an abrupt decline in AANAT mRNA level. A mathematical model for the AANAT mRNA profile and its experimental evidence with rat pinealocytes indicates that rhythmic AANAT mRNA degradation mediated by hnRNP R, hnRNP Q, and hnRNP L is a key process in the regulation of its circadian oscillation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.relation.isPartOf | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.title | Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1128/MCB.25.8.3232-3246.2005 | - |
dc.author.google | Kim, TD | - |
dc.author.google | Kim, JS | - |
dc.author.google | Kim, JH | - |
dc.author.google | Myung, J | - |
dc.author.google | Chae, HD | - |
dc.author.google | Woo, KC | - |
dc.author.google | Jang, SK | - |
dc.author.google | Koh, DS | - |
dc.author.google | Kim, KT | - |
dc.relation.volume | 25 | - |
dc.relation.issue | 8 | - |
dc.relation.startpage | 3232 | - |
dc.relation.lastpage | 3246 | - |
dc.contributor.id | 10104775 | - |
dc.relation.journal | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR BIOLOGY, v.25, no.8, pp.3232 - 3246 | - |
dc.identifier.wosid | 000228138500031 | - |
dc.date.tcdate | 2019-02-01 | - |
dc.citation.endPage | 3246 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3232 | - |
dc.citation.title | MOLECULAR AND CELLULAR BIOLOGY | - |
dc.citation.volume | 25 | - |
dc.contributor.affiliatedAuthor | Jang, SK | - |
dc.contributor.affiliatedAuthor | Kim, KT | - |
dc.identifier.scopusid | 2-s2.0-16244402306 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 55 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | NUCLEAR RIBONUCLEOPROTEIN R | - |
dc.subject.keywordPlus | MELATONIN SYNTHESIS | - |
dc.subject.keywordPlus | PINEAL-GLAND | - |
dc.subject.keywordPlus | FUNCTIONAL-CHARACTERIZATION | - |
dc.subject.keywordPlus | GENE-PRODUCT | - |
dc.subject.keywordPlus | HNRNP-R | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INTERACTS | - |
dc.subject.keywordPlus | CLONING | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
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