Nucleoside-based phospholipids and their liposomes formed in water

Abstract

Phospholipids and liposomes have been the subjects of considerable attention because of their importance in biological systems. We have efficiently synthesized novel nucleoside-based phospholipids in six-step sequences starting from their corresponding nucleosides. These nucleoside-based phospholipids self-assemble into lipsome-like structures in aqueous solutions. We have analyzed the structures of these lipsomes by dynamic light scattering, transmission electron microscopy, and confocal microscopy.